ZANGRADO® & PROGRADO® Benefits:

Zangrado® & Progrado® -  Patented, Highly Concentrated Substances: 

(Support studies listed in the Scientific Studies section) 

   Zangrado® and Zangrado® are patented extracts derived from the viscous red latex of the Croton species tree found primarily in the South American rainforests and is sustainably wild-crafted. RNI original research demonstrated their mechanism of action as regulating the sensory afferent neurons that line the internal organs as well as the skin

  • Powerful Proanthocyanidins  

  • Powerful Antioxidant Properties 

 

Both extracts affect over-stimulated sensory neurons and signal the central nervous system to respond. Orally, both Progrado and Zangrado have been effective in the treatment of nausea and ulcers with implications for irritable bowel syndrome and gastroesophageal reflux disease as well as other gastrointestinal complaints. Topically, Zangrado has been shown clinically

effective in reducing pain and itching associated with insect bites and stings, contact dermatitis, and plays a cicatrizing role in the healing process.

Sensory (afferent) neurons are nerves that respond to sensation – such as pain and itch – and are located throughout the body – lining the skin, organs and lungs.  In a sense, coughing is your body’s way of “itching” its lungs.

 

 Additionally, in human cells, Progrado has been shown to regulate overactive matrix metalloproteinases, molecular “scissors” from breaking down cartilage while increasing cellular IGF-1 levels.  

 

Zangrado® has been used in clinical trials topically to treat the pain and itch associated with bug bites and bee stings. It has been used internally to reduce nausea (emesis), diarrhea and also itch. Coughing is a method the lungs use to “itch” themselves so intuitively, Zangrado® would be effective internally for certain respiratory conditions. Progrado® has been shown to affect matrix metalloproteinase (MMPs). These are the molecular “scissors” that breakdown cartilage which is normally replaced by new cells.

Progrado® thus allows the body to repair itself.

 

Importantly, as with red wine, the proanthocyanidins found in Progrado® may offer benefits to the cardiovascular system.

ZANGRADO® & PROGRADO® Science:

Ingredient: Zangrado® and Progrado® - Works Cited:

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diarrhea in HIV-infected persons. Expert Rev Gastroenterol

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alkaloid taspine exhibit inhibition against human melanoma SK23 and colon

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latex. Phytomedicine. 2003 Mar;10(2-3):139-44.

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palanostigma induces apoptosis in human gastrointestinal cancer cells. J

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Additional Studies: 

  1. Bobrowski, PJ: Methods and preparations of the latex from the croton species. USPTO No. 7,208,183. 2007 April 24.

  2. Bobrowski PJ: Pharmaceutical preparations for the treatment of itch, nausea, hyperalgesia and the complications of opioid agonists.  USPTO No. 7,632,524. 2009 Dec 15.

  3. Bobrowski PJ: Method of treating emesis and itch.  USPTO No. 7,883,727.  2011 Feb 8, 2011.

  4. Miller M, Macnaughton W, Zhang X et al: Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado. Am J Physio Gastro Liver Physiology, 2000, 279: G192–G200. 

  5. Miller M, Vergnolle N, McKnight W et al: Inhibition of neurogenic inflammation by the Amazonian herbal medicine sangre de grado. Journal of Investigative Dermatology, 2001, 117(3): 725-730. 

  6. Miller M, Reuter B, Wallace J, Sharkey K, Bobrowski P: Mechanistic and Clinical Assessment of Zangrado, an Extract of the Amazonian Ethnomedicine Sangre de Grado, for the Treatment of Itch.  In: Yosipovitch G, Greaves MW, Fleischer AB, McGlone F, eds. Itch: Basic Mechanisms and Therapy. (pp. 305-315). New York: M. Dekker, 2004.

  7. Miller M, Bobrowski P, Shukla M et al: Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.  J Inflammation, 2007, 4:16. 

  8. Miller M, Reuter B, Wallace J et al: A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient. J Translational Medicine, 2008, 6: 3. 

  9. Sandoval M, Okuhama N, Clark M et al: Sangre de grado Croton palanostigma induces apoptosis in human gastrointestinal cancer cells. J Ethnopharm, 2002. 80:121-129. 

SMG, Inc., American Dream Nutrition, LLC. 2018 All rights reserved. No income claims or guarantees are made or implied. Individual results and incomes are determined by each person's efforts to build and promote their business.  *These statements have not been evaluated by the Food and Drug Administration. These products and information are not intended to diagnose, treat, cure or prevent disease. Take as directed and always consult with your doctor or healthcare professional before taking any supplements.