VINCARIA® Benefits:

Vincaria® - Is a Patented, Highly Concentrated Substance: 

  (Support studies listed in the Scientific Studies)

  • Clinically effective: Has been found in a preliminary study to reduce pain associated with activity in individuals with osteoarthritis of the knee. 

  • Mechanism of action is regulation of the TNF-alpha, powerful anti-inflammatory agent by regulating TNF alpha, the master “On-Off” switch in our bodies responsible for over thirty-five different types of inflammation.

 

  Vincaria® is a patented alkaloid-deplete extract from the Uncaria species vine shown in human clinical studies to reduce inflammation and pain associated with osteoarthritis. It’s mechanism of action is regulation of the TNF-alpha, a cytokine responsible in over 35 inflammatory pathways, via the NFkB. It also protects the gastrointestinal tract from NSAID (e.g. aspirin) induced injury, such as ulcers.

Inflammation is a key element and chronically active in many diseased states, including inflammatory bowel disease, arthritis, sepsis, gastritis, asthma, and atherosclerosis. Nuclear Factor Kappa B (NFkB) is a protein complex found in most cells that acts as the “on-off” switch for many genes involved in various

types of inflammation. 

 

 Beginning in 1998, scientists at LSU Medical School and later Albany Medical College began studying the two cat’s claw species. It was discovered that UG acts as a powerful anti-inflammatory agent by regulating TNF alpha, the master “On-Off” switch in our bodies responsible for over thirty-five different types of inflammation – from arthritis to asthma. When alkaloid traces were extracted and removed from UG, a patented process which created Vincaria®, it was even

more therapeutic.

 

Subsequently, a clinical trial was conducted in which a single once-a-day 100 milligram dose of Vincaria® was effective in ninety percent of patients, the majority in less than five days.  It was then used as an anti-inflammatory component, both to promote healthy skeletal, muscular and gastric health in obesity. In a separate trial, it was combined with a natural mineral supplement again successful for arthritis and later, with RNI 249, a maca extract, for osteoarthritis of the knee.

VINCARIA® Science: 

Ingredient: VINCARIA® - Works Cited:

 

(1) Mehta K, Gala J, Bhasale S et al: Comparison of glucosamine sulfate and a

polyherbal supplement for the relief of osteoarthritis of the knee: a

randomized controlled trial [ISRCTN25438351].BMC Complement Altern

Med. 2007 Oct 31;7:34. http://www.ncbi.nlm.nih.gov/pubmed/17974032

 

(2) Piscoya J, Rodriguez Z, Bustamante SA et al: Efficacy and safety of freezedried

cat's claw in osteoarthritis of the knee: mechanisms of action of the

species Uncaria guianensis. Inflamm Res. 2001 Sep;50(9):442-8.

http://www.ncbi.nlm.nih.gov/pubmed/11603848

 

(3) Miller MJ, Mehta K, Kunte S et al: Early relief of osteoarthritis symptoms

with a natural mineral supplement and a herbomineral combination: a

randomized controlled trial [ISRCTN38432711]. J Inflamm (Lond). 2005 Oct

21;2:11. http://www.ncbi.nlm.nih.gov/pubmed/16242032

 

(4) Sandoval M, Okuhama NN, Zhang XJ et al: Anti-inflammatory and

antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria

guianensis) are independent of their alkaloid content. Phytomedicine. 2002

May;9(4):325-37. http://www.ncbi.nlm.nih.gov/pubmed/12120814

 

(5) J. F. Gmelin, Carvalho MV, Penido C et al: Investigations on the antiinflammatory

and anti-allergic activities of the leaves of Uncaria guianensis

(Aublet). Inflammopharmacology. 2006 Mar;14(1-2):48-56.

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natural product are associated with the activation of IGF-1 production by

human chondrocytes despite the presence of IL-1beta. BMC Complement

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Additional Studies: ​

  1. Bobrowski PJ: Methods and preparations of extracts of Uncaria species with reduced alkaloid content. USPTO 6,797,286: Sep 28, 2004. 

  2. Carvalho M, Penido C, Siani A et al: Investigations on the anti-inflammatory and anti-allergic activities of the leaves of Uncaria guianensis (Aublet) J. F. Gmelin. Inflammopharmacology. 2006.14(1-2):48-56. 

  3. Hunter P. The inflammation theory of disease: The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment. EMBO Reports. 2012. 13(11):968-970.

  4. Hardin SR: Cat’s claw: an Amazonian vine decreases inflammation in osteoarthritis. Complement Ther Clin Pract. 2007. 13(1):25-28.

  5. Mehta K, Gala J, Bhasale S et al: Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. BMC Complement Altern Med. 2007. 7:34. 

  6. Miller M, Ahmed S, Bobrowski P et al: Suppression of Human Cartilage Degradation and Chondrocyte Activation by a Unique Mineral Supplement (SierraSil™) and a Cat’s Claw Extract, Vincaria®. JANA, 2004, 7(2): 32-39.

  7. Miller M, Angeles F, Reuter B et al: Dietary antioxidants protect gut epithelial cells from oxidant-induced apoptosis. BMC Complement Altern Med. 2001. 1:11.

  8. Miller M, Mehta K, Kunte S et al: Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. J Inflamm (Lond). 2005. 2:11.

  9. Miller M, Ahmed S, Bobrowski P et al: The chondroprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006. 6:13.

  10. Monaco C, Andreakos E, Kiriakidis S et al: Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc Natl Acad Sci U S A. 2004. 13;101(15):5634-9. 

  11. Piscoya J, Rodriguez Z, Bustamante S et al: Efficacy and safety of freeze-dried cat’s claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res. 2001.50(9):442-8. 

  12. Sandoval M, Okuhama NN, Zhang XJ et al: Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. 2002. 9(4):325-37. 

  13. Urdanibia I, Michelangeli F, Ruiz MC et al: Anti-inflammatory and antitumoural effects of Uncaria guianensis bark. J Ethnopharmacol. 2013. 150(3):1154-62. 

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