PhytoZon®
ASTRAGALUS Benefits:
Astragalus - (Astragalus membranaceus) root, also known as Milkvetch, has been used as a traditional Chinese medicine (TCM) for over 2,000 years. While it has be traditionally used to protect the liver, for aging, stress and the heart, date reveals that it may be effective in enhancing the immune system.
-
Also know as an Adaptogen
-
Telomeres Activity
(Support studies listed in the Scientific Studies)
Helps Support:
-
Immune System
-
Healthy Immune Cell Function
-
May help reduce seasonal allergies
ASTRAGALUS Science:
Ingredient: ASTRAGALUS - Works Cited:
(1) Brush J, Mendenhall E, Guggenheim A et al: The effect of Echinacea
purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69
expression and immune cell activation in humans. Phytother Res. 2006
Aug;20(8):687-95. http://www.ncbi.nlm.nih.gov/pubmed/16807880
(2) Mao SP, Cheng KL, Zhou YF et al: Modulatory effect of Astragalus
membranaceus on Th1/Th2 cytokine in patients with herpes simplex
keratitis. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3. (Chinese).
http://www.ncbi.nlm.nih.gov/pubmed/15015443
(3) Huang ZQ, Qin NP, Ye W: Effect of Astragalus membranaceus on Tlymphocyte
subsets in patients with viral myocarditis. Zhongguo Zhong Xi Yi
Jie He Za Zhi. 1995 Jun;15(6):328-30. (Chinese).
http://www.ncbi.nlm.nih.gov/pubmed/7549379
(4) Zhang X, Chen J: The mechanism of astragaloside IV promoting sciatic
nerve regeneration. Neural Regen Res. 2013 Aug 25;8(24):2256-65.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146037/
(5) Chen Z, Cai Y, Zhang W et al: Astragaloside IV inhibits platelet-derived
growth factor-BB-stimulated proliferation and migration of vascular smooth
muscle cells via the inhibition of p38 MAPK signaling. Exp Ther Med. 2014
Oct;8(4):1253-1258. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151649/
(6) Qiu YY, Zhu JX, Bian T et al: Protective Effects of Astragaloside IV against
Ovalbumin-Induced Lung Inflammation Are Regulated/Mediated by Tbet/
GATA-3.Pharmacology. 2014 Aug 28;94(1-2):51-59.
http://www.ncbi.nlm.nih.gov/pubmed/25171656
(7) Shao A, Guo S, Tu S etal: Astragaloside IV alleviates early brain injury
following experimental subarachnoid hemorrhage in rats. Int J Med Sci. 2014
Aug 8;11(10):1073-81.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135229/
(8) Yang M, Lin HB, Gong S et al: Effect of Astragalus polysaccharides on
expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis.
Cytokine. 2014 Aug 14.
http://www.sciencedirect.com/science/article/pii/S104346661400475X
(9) Ip FC, Ng YP, An HJ et al: Cycloastragenol Is a Potent Telomerase Activator
in Neuronal Cells: Implications for Depression Management. Neurosignals.
2014 Jul 31;22(1):52-63. http://www.ncbi.nlm.nih.gov/pubmed/25095809
(10) Fu J, Wang Z, Huang L et al: Review of the Botanical Characteristics,
Phytochemistry, and Pharmacology of Astragalus membranaceus (Huangqi).
Phytother Res. 2014 Sep;28(9):1275-83.
http://www.ncbi.nlm.nih.gov/pubmed/25087616
(11) Zhang A, Zheng Y, Que Z et al: Astragaloside IV inhibits progression of
lung cancer by mediating immune function of Tregs and CTLs by interfering
with IDO. J Cancer Res Clin Oncol. 2014 Jul 1.
http://www.ncbi.nlm.nih.gov/pubmed/25068786
(12) Dai H, Jia G, Liu X et al: Astragalus polysaccharide inhibits isoprenalineinduced
cardiac hypertrophy via suppressing Ca(2+)-mediated
calcineurin/NFATc3 and CaMKII signaling cascades. Environ Toxicol
Pharmacol. 2014 Jul;38(1):263-71.
http://www.ncbi.nlm.nih.gov/pubmed/24975447
(13) Sun Q, Jia N, Wang W et al: Protective effects of astragaloside IV against
amyloid beta1-42 neurotoxicity by inhibiting the mitochondrial permeability
transition pore opening. PLoS One. 2014 Jun 6;9(6):e98866.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048237/
(14) Gu J, Liu K, Li H et al: Astragalus saponin attenuates the expression of
fibrosis-related molecules in irradiated cardiac fibroblasts. Acta Biochim
Biophys Sin (Shanghai). 2014 Jun;46(6):492-501.
http://www.ncbi.nlm.nih.gov/pubmed/24739634
(15) Guo Q, Sun X, Zhang Z et al: The effect of Astragalus polysaccharide on
the Epstein-Barr virus lytic cycle. Acta Virol. 2014;58(1):76-80.
http://www.ncbi.nlm.nih.gov/pubmed/24717032
(16) Oh HA, Choi HJ, Kim NJ et al: Anti-stress effect of astragaloside IV in
immobilized mice. J Ethnopharmacol. 2014 May 14;153(3):928-
32.http://www.ncbi.nlm.nih.gov/pubmed/24709311
(17) Kim MH, Kim SH, Yang WM: Beneficial effects of Astragaloside IV for hair
loss via inhibition of Fas/Fas L- mediated apoptotic signaling. PLoS One. 2014
Mar 27;9(3):e92984. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968031/
(18) Chen X, May B, Di YM et al: Oral Chinese herbal medicine combined with
pharmacotherapy for stable COPD: a systematic review of effect on BODE
index and six minute walk test. PLoS One. 2014 Mar
12;9(3):e91830.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951501/
(19) Yeh TS, Chuang HL, Huang WC et al: Astragalus membranaceus improves
exercise performance and ameliorates exercise-induced fatigue in trained
mice. Molecules. 2014 Mar 3;19(3):2793-807.
http://www.ncbi.nlm.nih.gov/pubmed/24595275
(20) Yang J, Wang HX, Zhang YJ et al: Astragaloside IV attenuates
inflammatory cytokines by inhibiting TLR4/NF-кB signaling pathway in
isoproterenol-induced myocardial hypertrophy. J Ethnopharmacol. 2013 Oct
25. pii: S0378-8741(13)00724-
1.http://www.ncbi.nlm.nih.gov/pubmed/24513635
(21) Wang B, Chen MZ: Astragaloside IV possesses antiarthritic effect by
preventing interleukin 1β-induced joint inflammation and cartilage damage.
Arch Pharm Res. 2014 Jun;37(6):793-802.
http://www.ncbi.nlm.nih.gov/pubmed/24469603
(22) Yang J, Wang HX, Zhang YJ et al: Astragaloside IV attenuates
inflammatory cytokines by inhibiting TLR4/NF-кB signaling pathway in
isoproterenol-induced myocardial hypertrophy. J Ethnopharmacol. 2013 Dec
12;150(3):1062-70. http://www.ncbi.nlm.nih.gov/pubmed/24432369
(23) Jia Y, Zuo D, Li Z et al: Astragaloside IV inhibits doxorubicin-induced
cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via
activating the PI3K/Akt pathway. Chem Pharm Bull (Tokyo). 2014;62(1):45-53.
http://www.ncbi.nlm.nih.gov/pubmed/24390491
(24) Agyemang K, Han L, Liu E et al: Recent Advances in Astragalus
membranaceus Anti-Diabetic Research: Pharmacological Effects of Its
Phytochemical Constituents. Evid Based Complement Alternat Med.
2013;2013:654643. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855992/
(25) Jin M, Zhao K, Huang Q et al: Structural features and biological activities
of the polysaccharides from Astragalus membranaceus. Int J Biol Macromol.
2014 Mar;64:257-66. http://www.ncbi.nlm.nih.gov/pubmed/24325861
(26) In vitro and in vivo anti-cancer activity of formononetin on human
cervical cancer cell line HeLa. Jin YM, Xu TM, Zhao YH, Wang YC, Cui MH.
Tumour Biol. 2014 Mar;35(3):2279-84.
http://www.ncbi.nlm.nih.gov/pubmed/24272199
(27) Wang T, Xuan X, Li M et al: Astragalus saponins affect proliferation,
invasion and apoptosis of gastric cancer BGC-823 cells. Diagn Pathol. 2013
Oct 24;8:179. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818446/
(28) Wang SG, Xu Y, Chen JD et al: Astragaloside IV stimulates angiogenesis
and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway.
Molecules. 2013 Oct 16;18(10):12809-19. http://www.mdpi.com/1420-
3049/18/10/12809
(29) Yang B, Xiao B, Sun T: Antitumor and immunomodulatory activity of
Astragalus membranaceus polysaccharides in H22 tumor-bearing mice. Int J
Biol Macromol. 2013 Nov;62:287-90.
http://www.ncbi.nlm.nih.gov/pubmed/24060282
(30) Ren S, Zhang H, Mu Y et al: Pharmacological effects of Astragaloside IV: a
literature review. J Tradit Chin Med. 2013 Jun;33(3):413-6. Review.
http://www.journaltcm.com/modules/Journal/contents/stories/133/25.pdf
(31) Ma X, Zhang K, Li H et al: Extracts from Astragalus membranaceus limit
myocardial cell death and improve cardiac function in a rat model of
myocardial ischemia. J Ethnopharmacol. 2013 Oct 7;149(3):720-8.
http://www.ncbi.nlm.nih.gov/pubmed/23968862
(32) Lu L, Wang DT, Shi Y et al: Astragalus polysaccharide improves muscle
atrophy from dexamethasone- and peroxide-induced injury in vitro. Int J Biol
Macromol. 2013 Oct;61:7-16.
http://www.ncbi.nlm.nih.gov/pubmed/23817095
(33) Li W, Sun YN, Yan XT et al: NF-κB inhibitory activity of sucrose fatty acid
esters and related constituents from Astragalus membranaceus. J Agric Food
Chem. 2013 Jul 24;61(29):7081-8.
http://www.ncbi.nlm.nih.gov/pubmed/23815760
(34) Li W, Sun YN, Yan XT et al: Flavonoids from Astragalus membranaceus
and their inhibitory effects on LPS- stimulated pro-inflammatory cytokine
production in bone marrow-derived dendritic cells. Arch Pharm Res. 2014
Feb;37(2):186-92. http://www.ncbi.nlm.nih.gov/pubmed/23771500
(35) Kaczmarczyk-Sedlak I, Wojnar W, Zych M et al: Effect of formononetin on
mechanical properties and chemical composition of bones in rats with
ovariectomy-induced osteoporosis. Evid Based Complement Alternat Med.
2013;2013:457052. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666393/
(36) Li M, Ma RN, Li LH et al: Astragaloside IV reduces cerebral edema postischemia/
reperfusion correlating the suppression of MMP-9 and AQP4. Eur J
Pharmacol. 2013 Sep 5;715(1-3):189-95.
http://www.ncbi.nlm.nih.gov/pubmed/23747593
(37) Qi W, Niu J, Qin Q et al: Astragaloside IV attenuates glycated albumininduced
epithelial-to-mesenchymal transition by inhibiting oxidative stress in
renal proximal tubular cells. Cell Stress Chaperones. 2014 Jan;19(1):105-14.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857426/
(38) Wang H, Zhang Y, Xia T et al: Synergistic promotion of blood vessel
regeneration by astragaloside IV and ferulic acid from electrospun fibrous
mats. Mol Pharm. 2013 Jun 3;10(6):2394-403.
http://www.ncbi.nlm.nih.gov/pubmed/23651405
(39) Lai PK, Chan JY, Wu SB et al: Anti-inflammatory activities of an active
fraction isolated from the root of Astragalus membranaceus in RAW 264.7
macrophages. Phytother Res. 2014 Mar;28(3):395-404.
http://www.ncbi.nlm.nih.gov/pubmed/23640962
(40) Zhao M, Zhao J, He G et al: Effects of astragaloside IV on action potentials
and ionic currents in guinea-pig ventricular myocytes. Biol Pharm Bull.
2013;36(4):515-21. https://www.jstage.jst.go.jp/article/bpb/36/4/36_b12-
00655/_article
(41) Lee DY, Noh HJ, Choi J et al: Anti-inflammatory cycloartane-type saponins
of Astragalus membranaceus. Molecules. 2013 Mar 25;18(4):3725-32.
http://www.mdpi.com/1420-3049/18/4/3725
(42) Wan CP, Gao LX, Hou LF et al: Astragaloside II triggers T cell activation
through regulation of CD45 protein tyrosine phosphatase activity. Acta
Pharmacol Sin. 2013 Apr;34(4):522-30.
http://www.ncbi.nlm.nih.gov/pubmed/23524573
(43) Yang Y, Chin A, Zhang L et al: The role of traditional Chinese medicines in
osteogenesis and angiogenesis. Phytother Res. 2014 Jan;28(1):1-8.
http://www.ncbi.nlm.nih.gov/pubmed/23494901
(44) Gui D, Huang J, Guo Y et al: Astragaloside IV ameliorates renal injury in
streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated
inflammatory genes expression. Cytokine. 2013 Mar;61(3):970-7.
http://www.ncbi.nlm.nih.gov/pubmed/23434274
(45) Molgora B, Bateman R, Sweeney G et al: Functional assessment of
pharmacological telomerase activators in human T cells. Cells. 2013 Jan
14;2(1):57-66. http://www.mdpi.com/2073-4409/2/1/57
(46) Yang ZC, Qu ZH, Yi MJ et al: Astragalus extract attenuates allergic airway
inflammation and inhibits nuclear factor κB expression in asthmatic mice.
Am J Med Sci. 2013 Nov;346(5):390-5.
http://www.ncbi.nlm.nih.gov/pubmed/23267235
(47) Hong MJ, Ko EB, Park SK et al: Inhibitory effect of Astragalus
membranaceus root on matrix metalloproteinase-1 collagenase expression
and procollagen destruction in ultraviolet B-irradiated human dermal
fibroblasts by suppressing nuclear factor kappa-B activity. J Pharm
Pharmacol. 2013 Jan;65(1):142-8.
http://www.ncbi.nlm.nih.gov/pubmed/23215697
(48) Jin H, Luo Q, Zheng Y et al: CD4+CD25+Foxp3+ T cells contribute to the
antiasthmatic effects of Astragalus membranaceus extract in a rat model of
asthma. Int Immunopharmacol. 2013 Jan;15(1):42-9.
http://www.ncbi.nlm.nih.gov/pubmed/23186751
(49) Yan L, Zhou QH: Study on neuroprotective effects of astragalan in rats
with ischemic brain injury and its mechanisms. Zhongguo Ying Yong Sheng Li
Xue Za Zhi. 2012 Jul;28(4):373-7. (Chinese).
http://www.ncbi.nlm.nih.gov/pubmed/23156741
(50) Kang SC, Kim HJ, Kim MH: Effects of Astragalus membranaceus with
supplemental calcium on bone mineral density and bone metabolism in
calcium-deficient ovariectomized rats. Biol Trace Elem Res. 2013
Jan;151(1):68-74. http://www.ncbi.nlm.nih.gov/pubmed/23136088
(51) Liu J, Zhang JF, Lu JZ et al: Astragalus polysaccharide stimulates glucose
uptake in L6 myotubes through AMPK activation and AS160/TBC1D4
phosphorylation. Acta Pharmacol Sin. 2013 Jan;34(1):137-45.
http://www.ncbi.nlm.nih.gov/pubmed/23103623
(52) Chen W, Xia Y, Zhao X et al: The critical role of Astragalus polysaccharides
for the improvement of PPARα [correction of PPRAα]-mediated lipotoxicity in
diabetic cardiomyopathy. PLoS One. 2012;7(10):e45541.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.004
5541
(53) Zhao J, Yang P, Li F et al: Therapeutic effects of astragaloside IV on
myocardial injuries: multi-target identification and network analysis. PLoS
One. 2012;7(9):e44938.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.004
4938
(54) Auyeung KK, Law PC, Ko JK: Novel anti-angiogenic effects of
formononetin in human colon cancer cells and tumor xenograft. Oncol Rep.
2012 Dec;28(6):2188-94. http://www.ncbi.nlm.nih.gov/pubmed/23023137
(55) Du X, Zhao B, Li J et al: Astragalus polysaccharides enhance immune
responses of HBV DNA vaccination via promoting the dendritic cell
maturation and suppressing Treg frequency in mice. Int Immunopharmacol.
2012 Dec;14(4):463-70. http://www.ncbi.nlm.nih.gov/pubmed/23006659
(56) Yang C, Ma Z: Expression of inducible nitric oxide synthase in restenosis
rats and function of Astragalus membranaceus and Angelica sinensis.
Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1655-8. (Chinese).
http://www.ncbi.nlm.nih.gov/pubmed/22994002
(57) Qin Q, Niu J, Wang Z et al: Astragalus membranaceus Inhibits
Inflammation via Phospho-P38 Mitogen- Activated Protein Kinase (MAPK) and
Nuclear Factor (NF)-κB Pathways in Advanced Glycation End Product-
Stimulated Macrophages. Int J Mol Sci. 2012;13(7):8379-87.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430240/
(58) Wang Y, Zhu Y, Gao L et al: Formononetin attenuates IL-1β-induced
apoptosis and NF-κB activation in INS-1 cells. Molecules. 2012 Aug
24;17(9):10052-64. http://www.mdpi.com/1420-3049/17/9/10052
(59) Tian QE, De Li H, Yan M et al: Effects of Astragalus polysaccharides on Pglycoprotein
efflux pump function and protein expression in H22 hepatoma
cells in vitro. BMC Complement Altern Med. 2012 Jul 11;12:94.
http://www.biomedcentral.com/1472-6882/12/94
(60) Qin Q, Niu J, Wang Z et al: Astragalus embranaceus extract activates
immune response in macrophages via heparanase. Molecules. 2012 Jun
13;17(6):7232-40. http://www.mdpi.com/1420-3049/17/6/7232
(61) Li FL, Li X, Wang YF et al: Astragaloside IV Downregulates β-Catenin in Rat
Keratinocytes to Counter LiCl-Induced Inhibition of Proliferation and
Migration. Evid Based Complement Alternat Med. 2012; 2012:956107.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368212/
(62) Lai PK, Chan JY, Cheng L et al: Isolation of anti-inflammatory fractions
and compounds from the root of Astragalus membranaceus. Phytother Res.
2013 Apr;27(4):581-7. http://www.ncbi.nlm.nih.gov/pubmed/22693074
(63) Kim W, Kim SH, Park SK et al: Astragalus membranaceus ameliorates
reproductive toxicity induced by cyclophosphamide in male mice. Phytother
Res. 2012 Sep;26(9):1418-21. Jun 2.
http://www.ncbi.nlm.nih.gov/pubmed/22674751
(64) You Y, Duan Y, Liu SW et al: Anti-atherosclerotic function of Astragali
Radix extract: downregulation of adhesion molecules in vitro and in vivo.
BMC Complement Altern Med. 2012 Apr 26;12:54.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478196/
(65) Li Q, Bao JM, Li XL et al: Inhibiting effect of Astragalus polysaccharides on
the functions of CD4+CD25 highTreg cells in the tumor microenvironment of
human hepatocellular carcinoma. Chin Med J (Engl). 2012 Mar;125(5):786-93.
http://www.cmj.org/ch/reader/view_abstract.aspx?volume=125&issue=5&sta
rt_page=786
(66) Chen CC, Lee HC, Chang JH et al: Chinese Herb Astragalus
membranaceus Enhances Recovery of Hemorrhagic Stroke: Double-Blind,
Placebo-Controlled, Randomized Study. Evid Based Complement Alternat
Med. 2012;2012:708452.
http://www.hindawi.com/journals/ecam/2012/708452/
(67) Han XH, Liu P, Zhang YY et al: Astragaloside IV regulates expression of
ATP-sensitive potassium channel subunits after ischemia-reperfusion in rat
ventricular cardiomyocytes. J Tradit Chin Med. 2011 Dec;31(4):321-6.
http://www.ncbi.nlm.nih.gov/pubmed/22462239
(68) He X, Shu J, Xu L et al: Inhibitory effect of Astragalus polysaccharides on
lipopolysaccharide-induced TNF-a and IL-1β production in THP-1 cells.
Molecules. 2012 Mar 12;17(3):3155-64. http://www.mdpi.com/1420-
3049/17/3/3155
(69) Xiong M, He Q, Lai H et al: Astragaloside IV inhibits apoptotic cell death in
the guinea pig cochlea exposed to impulse noise. Acta Otolaryngol. 2012
May;132(5):467-74. http://www.ncbi.nlm.nih.gov/pubmed/22217340
(70) Huang LH, Yan QJ, Kopparapu NK et al: Astragalus membranaceus lectin
(AML) induces caspase-dependent apoptosis in human leukemia cells. Cell
Prolif. 2012 Feb;45(1):15-21. http://www.ncbi.nlm.nih.gov/pubmed/22172162
(71) Ye MN, Chen HF, Zhou RJ et al: Effects of Astragalus polysaccharide on
proliferation and Akt phosphorylation of the basal-like breast cancer cell line.
Zhong Xi Yi Jie He Xue Bao. 2011 Dec;9(12):1339-46. (Chinese).
http://www.jcimjournal.com/jim/showAbstrPage.aspx?articleid=jcim20111210
(72) Jia R, Cao L, Xu P et al: In vitro and in vivo hepatoprotective and
antioxidant effects of Astragalus polysaccharides against carbon
tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio).
Fish Physiol Biochem. 2012 Jun;38(3):871-81.
http://www.ncbi.nlm.nih.gov/pubmed/22089693
(73) Zheng R, Deng Y, Chen Y et al: Astragaloside IV attenuates complement
membranous attack complex induced podocyte injury through the MAPK
pathway. Phytother Res. 2012 Jun;26(6):892-8.
http://www.ncbi.nlm.nih.gov/pubmed/22086717
(74) Du X, Chen X, Zhao B et al: Astragalus polysaccharides enhance the
humoral and cellular immune responses of hepatitis B surface antigen
vaccination through inhibiting the expression of transforming growth factor
β and the frequency of regulatory T cells. FEMS Immunol Med Microbiol.
2011 Nov;63(2):228-35. http://www.ncbi.nlm.nih.gov/pubmed/22077226
(75) Yang B, Ji C, Chen X et al: Protective effect of astragaloside IV against
matrix metalloproteinase-1 expression in ultraviolet-irradiated human
dermal fibroblasts. Arch Pharm Res. 2011 Sep;34(9):1553-60.
http://www.ncbi.nlm.nih.gov/pubmed/21975818
(76) Zhao LH, Ma ZX, Zhu J et al: Characterization of polysaccharide from
Astragalus radix as the macrophage stimulator. Cell Immunol.
2011;271(2):329-34. http://www.ncbi.nlm.nih.gov/pubmed/21937031
(77) Chen R, Shao H, Lin S et al: Treatment with Astragalus membranaceus
produces antioxidative effects and attenuates intestinal mucosa injury
induced by intestinal ischemia-reperfusion in rats. Am J Chin Med.
2011;39(5):879-87. http://www.ncbi.nlm.nih.gov/pubmed/21905279
(78) Hu XY, Xia RX, Cheng CB et al: Mechanism of apoptosis in human
leukemia NB4 cells induced by total astragalosides. Zhonghua Zhong Liu Za
Zhi. 2011 May;33(5):345-8. (Chinese).
http://www.ncbi.nlm.nih.gov/pubmed/21875462
(79) Auyeung KK, Woo PK, Law PC et al: Astragalus saponins modulate cell
invasiveness and angiogenesis in human gastric adenocarcinoma cells. J
Ethnopharmacol. 2012 Jun 1;141(2):635-41.
http://www.ncbi.nlm.nih.gov/pubmed/21864667
(80) Collins RA: A ten-year audit of traditional Chinese medicine and other
natural product research published in the Chinese Medical Journal (2000-
2009). Chin Med J (Engl). 2011 May;124(9):1401-8.
http://www.cmj.org/ch/reader/view_abstract.aspx?volume=124&issue=9&sta
rt_page=1401
(81) Zhang L, Liu Q, Lu L et al: Astragaloside IV stimulates angiogenesis and
increases hypoxia-inducible factor-1α accumulation via phosphatidylinositol
3-kinase/Akt pathway. J Pharmacol Exp Ther. 2011 Aug;338(2):485-91.
http://jpet.aspetjournals.org/content/338/2/485.long
(82) Zhang N, Wang XH, Mao SL et al: Astragaloside IV improves metabolic
syndrome and endothelium dysfunction in fructose-fed rats. Molecules. 2011
May 10;16(5):3896-907. http://www.mdpi.com/1420-3049/16/5/3896
(83) Li SG, Chen Y, Zhang YQ: Effects of Astragalus polysaccharide on
nephritis induced by cationic bovine serum albumin in rats. Zhong Yao Cai.
2010 Dec;33(12):1913-6. (Chinese).
http://www.ncbi.nlm.nih.gov/pubmed/21548372
(84) Xiong M, Lai H, He Q et al: Astragaloside IV attenuates impulse noiseinduced
trauma in guinea pig..Acta Otolaryngol. 2011 Aug;131(8):809-16.
http://www.ncbi.nlm.nih.gov/pubmed/21526907
(85) Shang L, Qu Z, Sun L et al: Astragaloside IV inhibits adenovirus replication
and apoptosis in A549 cells in vitro. J Pharm Pharmacol. 2011 May;63(5):688-
94. http://www.ncbi.nlm.nih.gov/pubmed/21492171
(86) Zhang L, Yang Y, Wang Y et al: Astragalus membranaceus extract
promotes neovascularisation by VEGF pathway in rat model of ischemic
injury. Pharmazie. 2011 Feb;66(2):144-50.
http://www.ncbi.nlm.nih.gov/pubmed/21434579
(87) Bernardes de Jesus B, Schneeberger K, Vera E, Tejera A et al: The
telomerase activator TA-65 elongates short telomeres and increases health
span of adult/old mice without increasing cancer incidence. Aging Cell. 2011
Aug;10(4):604-21. http://onlinelibrary.wiley.com/doi/10.1111/j.1474-
9726.2011.00700.x/full
(88) Wang YJ, Yu YR: Protective effects of Astragalus membranaceus on free
fatty acid-induced vascular endothelial cell dysfunction. Sichuan Da Xue Xue
Bao Yi Xue Ban. 2011 Jan;42(1):48-51. (Chinese).
http://www.ncbi.nlm.nih.gov/pubmed/21355300
(89) Zhang LJ, Liu HK, Hsiao PC et al: New isoflavonoid glycosides and related
constituents from astragali radix (Astragalus membranaceus ) and their
inhibitory activity on nitric oxide production. J Agric Food Chem. 2011 Feb
23;59(4):1131-7. http://www.ncbi.nlm.nih.gov/pubmed/21280630
(90) Harley CB, Liu W, Blasco M et al: A natural product telomerase activator
as part of a health maintenance program. Rejuvenation Res. 2011
Feb;14(1):45-56. http://online.liebertpub.com/doi/pdf/10.1089/rej.2010.1085
(91) Zhang CL, Kong XL, Chen SX et al: Effect of astragalus membranaceus on
the proliferation, osteogenic capacity and structure of periodontal ligament
cells in vitro. Hua Xi Kou Qiang Yi Xue Za Zhi. 2010 Oct;28(5):556-9. (Chinese).
http://www.ncbi.nlm.nih.gov/pubmed/21179698
(92) Tang D, He B, Zheng ZG et al: Inhibitory effects of two major
isoflavonoids in Radix Astragali on high glucose-induced mesangial cells
proliferation and AGEs-induced endothelial cells apoptosis. Planta Med. 2011
May;77(7):729-32. http://www.ncbi.nlm.nih.gov/pubmed/21157685
(93) Li YR, Cao W, Guo J et al: Comparative investigations on the protective
effects of rhodioside, ciwujianoside- B and astragaloside IV on radiation
injuries of the hematopoietic system in mice. Phytother Res. 2011
May;25(5):644-53. http://www.ncbi.nlm.nih.gov/pubmed/21031634
(94) Huh JE, Nam DW, Baek YH et al: Formononetin accelerates wound repair
by the regulation of early growth response factor-1 transcription factor
through the phosphorylation of the ERK and p38 MAPK pathways. Int
Immunopharmacol. 2011 Jan;11(1):46-54.
http://www.ncbi.nlm.nih.gov/pubmed/20959155
(95) Li M, Wang W, Xue J et al: Meta-analysis of the clinical value of Astragalus
membranaceus in diabetic nephropathy. J Ethnopharmacol. 2011 Jan
27;133(2):412-9. http://www.ncbi.nlm.nih.gov/pubmed/20951192
(96) Jaskelioff M, Muller FL, Paik JH et al: Telomerase reactivation reverses
tissue degeneration in aged telomerase-deficient mice. Nature. 2011 Jan
6;469(7328):102-6.
http://www.ncbi.nlm.nih.gov/pubmed/21113150?dopt=Abstract&holding=npg
(97) Effects of astragalus on cardiac function and serum tumor necrosis
factor-alpha level in patients with chronic heart failure. Zhongguo Zhong Xi Yi
Jie He Za Zhi. 2010 Jul;30(7):699-701. (Chinese).
http://www.ncbi.nlm.nih.gov/pubmed/20929124
(98) Denzler KL, Waters R, Jacobs BL et al: Regulation of inflammatory gene
expression in PBMCs by immunostimulatory botanicals. PLoS One. 2010 Sep
3;5(9):e12561. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933230/
(99) Callaway E: Telomerase reverses ageing process. Nature. 28 November
2010 doi:10.1038/news.2010.635
http://www.nature.com/news/2010/101128/full/news.2010.635.html
(100) Abbott A: Chromosome protection scoops Nobel. Nature. 2009 Oct 461:
706-707. http://www.nature.com/news/2009/091005/full/461706a.html
(101) Ledford H: Minimum telomere length defined for healthy cells. Nature.
2007 Oct 449: 515.
http://www.nature.com/news/2007/071003/full/449515a.html
Additional Studies:
-
Bao-Mei S, Xu W, Dai H et al: A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Comm. 2004. 1103–1111.
-
Block K, Mead M: Immune System Effects of Echinacea, Ginseng, and Astragalus: A Review. Int Cancer Ther. 2003. 2(3):247-267.
-
Boroujerdnia M, Azemi M, Hemmati A et al: Immunomodulatory Effects of Astragalus gypsicolus Hydroalcoholic Extract in Ovalbumin-Induced Allergic Mice Model. Iran J Allergy Asthma Immunol. 2011. 10(4):281-288.
-
Brush J, Mendenhall E, Guggenheim A et al: The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Phytother Res. 2006. 20(8):687-95.
-
Jiang D, Wang X, Su Q et al: Milkvetch root improves immune function in patients with acute exacerbation of COPD. Biomed Mater Eng. 2015. S2113-21.
-
Mao S, Cheng K, Zhou Y: [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. [Article in Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004. 24(2):121-3.
-
Matkovic Z, Zivkovic V, Korica M et al: Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res. 2010. 24(2):175-81.
-
Shih-Ming C, Tsai y, Lee S et al: Astragalus membranaceus modulates Th1/2 immune balance and activates PPARγ in a murine asthma model. Biochemistry and Cell Biology. 2014. 92(5):397-405.
-
Su G, Chen X, Liu Z et al: Oral Astragalus (Huang qi) for preventing frequent episodes of acute respiratory tract infection in children. Cochrane Database of Systematic Reviews. 2015. 11:CD011958.
-
Zwickey H, Brush J, Iacullo C et al: The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study. Phytother Res. 2007. 21(11):1109-12.
SMG, Inc., American Dream Nutrition, LLC. 2018 All rights reserved. No income claims or guarantees are made or implied. Individual results and incomes are determined by each person's efforts to build and promote their business. *These statements have not been evaluated by the Food and Drug Administration. These products and information are not intended to diagnose, treat, cure or prevent disease. Take as directed and always consult with your doctor or healthcare professional before taking any supplements.