PhytoZon®
RNI249® Benefits:
RNI249® - Is a Patented, Highly Concentrated Substance:
(Support studies under "Scientific Studies")
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RNI249® Is the only known natural substance or pharmaceutical shown to increase endogenous IGF-1 in human cells
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Research supported by two National Institutes of Health: National Institute of Aging and the National Institute of Arthritis and Musculoskeletal Disease
Helps Support:
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Endogenous IGF-1 Secretion
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Healthy Aging
RNI 249® is a patented extract from the hypocotyls of the crucifer Lepidium meyenii (aka “Maca”), a radish-like tuber cultivated only on the inner slopes of the Andean Mountains. In a study with Case Western Reserve University, it has been shown to increase human cellular production of IGF-1 and in a clinical trial, together with Vincaria®, was an effective treatment for osteoporosis.
The pituitary gland in the brain secretes human growth hormone (HGH) which in turn signals (primarily) the liver to produce and secrete insulin like growth factor 1 (IGF-1). Both HGH and IGF-1 promote whole body growth and their levels peak during puberty. IGF-1 increases protein synthesis (muscle growth), bone mineralization, low blood sugar, kidney function and insulin sensitivity. It promotes healing and repair of bone, muscle, nervous system and immune system cells.
Following puberty when its levels are at their peak, as we age, IGF-1 levels precipitously decline such that by the time we are 60 years old, the levels have decreased by approximately eighty percent (80%).
This natural decline in IGF-1 levels in adulthood, known as somatopause, is responsible for most of the signs we associate with aging. These include but are not limited to altered musculoskeletal function (e.g. muscle atrophy; associated decrease in strength; bone calcium loss/osteoporosis); altered endocrine function (i.e. a higher incidence of diabetes); altered carbohydrate and lipid metabolism; altered Integumentary function (e.g. skin thinning, wrinkles); and, altered neurological function (e.g. dementia, Alzheimer disease).
To date, RNI 249 is the only substance, natural or pharmaceutical, which has been shown to increase the body’s natural production of IGF.
As proof of principle, researchers subsequently conducted a human clinical trial, sponsored in part by the NIH/NIA, in subjects with confirmed osteoarthritis. Within the 30-day period of the trial and then for most within seven days, 94% of the participants had a statistically significant improvement in mobility and flexibility and in comparison to the positive control glucosamine, a marked reduction in pain.
RNI249® Science:
Ingredient: RNI249® - Works Cited:
(1) Andrews K, Grunebaum AN: Composition and method for fertility therapy
using nutritional supplements. USPTO No. 8,663,709. 2014 Mar 4.
http://patft.uspto.gov/netacgi/nph-
Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%
2Fsrchnum.htm&r=1&f=G&l=50&s1=8,663,709.PN.&OS=PN/8,663,709&RS=P
N/8,663,709
(2) Zhang Y, Yu L, Jin W, Ao M: Effect of ethanolic extract of Lepidium meyenii
Walp on serum hormone levels in ovariectomized rats. Indian J Pharmacol.
2014 Jul;46(4):416-9. http://www.ncbi.nlm.nih.gov/pubmed/25097281
(3) Zha S, Zhao Q, Chen J et al: Extraction, purification and antioxidant
activities of the polysaccharides from maca (Lepidium meyenii). Carbohydr
Polym. 2014 Oct 13;111:584-7.
http://www.ncbi.nlm.nih.gov/pubmed/25037390
(4) Hajdu Z, Nicolussi S, Rau M et al: Identification of Endocannabinoid
System-Modulating N-Alkylamides from Heliopsis helianthoides var. scabra
and Lepidium meyenii. J Nat Prod. 2014 Jul 25;77(7):1663-9.
http://www.ncbi.nlm.nih.gov/pubmed/24972328
(5) Stojanovska L, Law C, Lai B et al Maca reduces blood pressure and
depression, in a pilot study in postmenopausal women. Climacteric. 2014
Aug 7:1-10. http://www.ncbi.nlm.nih.gov/pubmed/24931003
(6) Ai Z, Cheng AF, Yu YT et al: Antidepressant-like behavioral, anatomical, and
biochemical effects of petroleum ether extract from maca (Lepidium
meyenii) in mice exposed to chronic unpredictable mild stress. J Med Food.
2014 May;17(5):535-42. http://www.ncbi.nlm.nih.gov/pubmed/24730393
(7) Benites Goñi HE, Cok García J, Bussalleu Cavero A et al: Assesing the effect
of Lepidium meyenii "Maca" on the gastric mucosa in patients with functional
dyspepsia. Rev Gastroenterol Peru. 2014 Jan-Mar;34(1):39-43 (Spanish).
http://www.ncbi.nlm.nih.gov/pubmed/24721957
(8) Gonzales GF, Villaorduña L, Gasco M, Rubio J et al: Maca (Lepidium
meyenii Walp), a review of its biological properties. Rev Peru Med Exp Salud
Publica. 2014;31(1):100-10 (Spanish).
http://www.ncbi.nlm.nih.gov/pubmed/24718534
(9) Lembè DM, Gasco M, Gonzales GF:Synergistic effect of the hydroalcoholic
extract from Lepidium meyenii (Brassicaceae) and Fagara tessmannii
(Rutaceae) on male sexual organs and hormone level in rats. Pharmacognosy
Res. 2014 Jan;6(1):80-6. http://www.ncbi.nlm.nih.gov/pubmed/24497748
(10) Uchiyama F, Jikyo T, Takeda R et al: Lepidium meyenii (Maca) enhances
the serum levels of luteinising hormone in female rats. J Ethnopharmacol.
2014 Feb 3;151(2):897-902. http://www.ncbi.nlm.nih.gov/pubmed/24333960
(11) Gonzales GF, Gasco M, Lozada-Requena I: Role of maca (Lepidium
meyenii) consumption on serum interleukin-6 levels and health status in
populations living in the Peruvian Central Andes over 4000 m of altitude.
Plant Foods Hum Nutr. 2013 Dec;68(4):347-51.
http://www.ncbi.nlm.nih.gov/pubmed/23934543
(12) Wu H, Kelley CJ, Pino-Figueroa A et al: Macamides and their synthetic
analogs: evaluation of in vitro FAAH inhibition. Bioorg Med Chem. 2013 Sep
1;21(17):5188-97. http://www.ncbi.nlm.nih.gov/pubmed/23891163
(13) Almukadi H, Wu H, Böhlke M et al: The macamide N-3-methoxybenzyllinoleamide
is a time-dependent fatty acid amide hydrolase (FAAH) inhibitor.
Mol Neurobiol. 2013 Oct;48(2):333-9.
http://www.ncbi.nlm.nih.gov/pubmed/23853040
(14) Gonzales GF, Vasquez VB, Gasco M: The transillumination technique as a
method for the assessment of spermatogenesis using medicinal plants: the
effect of extracts of black maca (Lepidium meyenii) and camu camu
(Myrciaria dubia) on stages of the spermatogenic cycle in male rats. Toxicol
Mech Methods. 2013 Oct;23(8):559-65.
http://www.ncbi.nlm.nih.gov/pubmed/23650963
(15) Gonzales GF, Gonzales-Castañeda C, Gasco M: A mixture of extracts from
Peruvian plants (black maca and yacon) improves sperm count and reduced
glycemia in mice with streptozotocin-induced diabetes. Toxicol Mech
Methods. 2013 Sep;23(7):509-18.
http://www.ncbi.nlm.nih.gov/pubmed/23489070
(16) Shrivastava A, Gupta VB: Various treatment options for benign prostatic
hyperplasia: A current update. J Midlife Health. 2012 Jan;3(1):10-9.
http://www.ncbi.nlm.nih.gov/pubmed/22923974
(17) Clément C, Witschi U, Kreuzer M: The potential influence of plant-based
feed supplements on sperm quantity and quality in livestock: a review. Anim
Reprod Sci. 2012 May;132(1-2):1-10.
http://www.ncbi.nlm.nih.gov/pubmed/22575847
(18) Bobrowski, PJ: Methods and compositions to enhance endogenous IGF
production and their use. USPTO No. 8182847: 2012 May 22.
http://patft.uspto.gov/netacgi/nph-
Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.
html&r=11&f=G&l=50&co1=AND&d=PTXT&s1=Paul&s2=Bobrowski&OS=
Paul+AND+Bobrowski&RS=Paul+AND+Bobrowski
(19) Gonzales GF: Ethnobiology and Ethnopharmacology of Lepidium meyenii
(Maca), a Plant from the Peruvian Highlands. Evid Based Complement
Alternat Med. 2012; 2012:193496.
http://www.ncbi.nlm.nih.gov/pubmed/21977053
(20) Zhao J, Avula B, Chan M et al: Metabolomic differentiation of maca
(Lepidium meyenii) accessions cultivated under different conditions using
NMR and chemometric analysis. Planta Med. 2012 Jan;78(1):90-101.
http://www.ncbi.nlm.nih.gov/pubmed/21858755
(21) Bobrowski P: Methods and compositions to enhance endogenous IGF
production and their uses. USPTO 8,182,847: May 22, 2012.
(22) Akhtar N, Miller MJ, Haqqi TM: Effect of a Herbal-Leucine mix on the IL-
1β-induced cartilage degradation and inflammatory gene expression in
human chondrocytes. BMC Complement Altern Med. 2011 Aug 19;11:66.
http://www.ncbi.nlm.nih.gov/pubmed/21854562
(23) Lee MS, Shin BC, Yang EJ et al: Maca (Lepidium meyenii) for treatment of
menopausal symptoms: A systematic review. Maturitas. 2011 Nov;70(3):227-
33. http://www.ncbi.nlm.nih.gov/pubmed/21840656
(24) Gonzales-Castañeda C, Rivera V, Chirinos AL et al: Photoprotection
against the UVB-induced oxidative stress and epidermal damage in mice
using leaves of three different varieties of Lepidium meyenii (maca).
(25) Int J Dermatol. 2011 Aug;50(8):928-38.
http://www.ncbi.nlm.nih.gov/pubmed/21781063
(26) Rubio J, Yucra S, Gasco M et al: Dose-response effect of black maca
(Lepidium meyenii) in mice with memory impairment induced by ethanol.
Toxicol Mech Methods. 2011 Oct;21(8):628-34.
http://www.ncbi.nlm.nih.gov/pubmed/21780878
(27) Rubio J, Qiong W, Liu X et al: Aqueous Extract of Black Maca (Lepidium
meyenii) on Memory Impairment Induced by Ovariectomy in Mice. Evid
Based Complement Alternat Med. 2011;2011:253958.
http://www.ncbi.nlm.nih.gov/pubmed/18955369
(28) Gonzales C, Leiva-Revilla J, Rubio J et al: Effect of red maca (Lepidium
meyenii) on prostate zinc levels in rats with testosterone-induced prostatic
hyperplasia. Andrologia. 2012 May;44 Suppl 1:362-9.
http://www.ncbi.nlm.nih.gov/pubmed/21762188
(29) Clément C, Diaz Grados DA, Avula B et al: Influence of colour type and
previous cultivation on secondary metabolites in hypocotyls and leaves of
maca (Lepidium meyenii Walpers). J Sci Food Agric. 2010 Apr 15;90(5):861-9.
http://www.ncbi.nlm.nih.gov/pubmed/20355123
(30) Mazaro-Costa R, Andersen ML, Hachul H, Tufik S.: Medicinal plants as
alternative treatments for female sexual dysfunction: utopian vision or
possible treatment in climacteric women? J Sex Med. 2010 Nov; 7(11):3695-
714. http://www.ncbi.nlm.nih.gov/pubmed/20722793
(31) Zheng BL, He K, Shao Y et al: Compositions and methods for their
preparation from lepidium. USPTO No. RE43,005. 2001 Dec 6.
http://patft.uspto.gov/netacgi/nphParser?
Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.
html&r=11&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O
S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii
(32) Pino-Figueroa A, Nguyen D, Maher TJ: Neuroprotective effects of
Lepidium meyenii (Maca). Ann N Y Acad Sci. 2010 Jun;1199:77-85.
http://www.ncbi.nlm.nih.gov/pubmed/20633111
(33) Ranilla LG, Kwon YI, Apostolidis E et al: Phenolic compounds, antioxidant
activity and in vitro inhibitory potential against key enzymes relevant for
hyperglycemia and hypertension of commonly used medicinal plants, herbs
and spices in Latin America. Bioresour Technol. 2010 Jun;101(12):4676-89.
http://www.ncbi.nlm.nih.gov/pubmed/20185303
(34) Clément C, Kneubühler J, Urwyler A et al: Effect of maca supplementation
on bovine sperm quantity and quality followed over two spermatogenic
cycles. Theriogenology. 2010 Jul 15;74(2):173-83.
http://www.ncbi.nlm.nih.gov/pubmed/20452008
(35) Shin BC, Lee MS, Yang EJ et al: Maca (L. meyenii) for improving sexual
function: a systematic review.BMC Complement Altern Med. 2010 Aug
6;10:44. http://www.ncbi.nlm.nih.gov/pubmed/20691074
(36) Gonzales C, Cárdenas-Valencia I, Leiva-Revilla J et al: Effects of different
varieties of Maca (Lepidium meyenii) on bone structure in ovariectomized
rats. Forsch Komplementmed. 2010;17(3):137-43.
http://www.ncbi.nlm.nih.gov/pubmed/20616517
(37) Gonzales GF, Gonzales C, Gonzales-Castañeda C: Lepidium meyenii
(Maca): a plant from the highlands of Peru--from tradition to science. Forsch
Komplementmed. 2009 Dec;16(6):373-80.
http://www.ncbi.nlm.nih.gov/pubmed/20090350
(38) Stone M, Ibarra A, Roller M et al: A pilot investigation into the effect of
maca supplementation on physical activity and sexual desire in sportsmen. J
Ethnopharmacol. 2009 Dec 10;126(3):574-6.
http://www.ncbi.nlm.nih.gov/pubmed/19781622
(39) Zenico T, Cicero AF, Valmorri L et al: Subjective effects of Lepidium
meyenii (Maca) extract on well-being and sexual performances in patients
with mild erectile dysfunction: a randomized, double-blind clinical trial.
Andrologia. 2009 Apr;41(2):95-9.
http://www.ncbi.nlm.nih.gov/pubmed/19260845
(40) Gonzales-Castañeda C, Gonzales GF: Hypocotyls of Lepidium meyenii
(maca), a plant of the Peruvian highlands, prevent ultraviolet A-, B-, and Cinduced
skin damage in rats. Photodermatol Photoimmunol Photomed. 2008
Feb;24(1):24-31. http://www.ncbi.nlm.nih.gov/pubmed/18201354
(41) Valentová K, Stejskal D, Bartek J et al: Maca (Lepidium meyenii) and
yacon (Smallanthus sonchifolius) in combination with silymarin as food
supplements: in vivo safety assessment. Food Chem Toxicol. 2008
Mar;46(3):1006-13. http://www.ncbi.nlm.nih.gov/pubmed/18054420
(42) Gonzales GF, Gasco M, Malheiros-Pereira A et al: Antagonistic effect of
Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice.
Andrologia. 2008 Jun;40(3):179-85.
http://www.ncbi.nlm.nih.gov/pubmed/18477205
(43) Dording CM, Fisher L, Papakostas G et al: A double-blind, randomized,
pilot dose-finding study of maca root (L. meyenii) for the management of
SSRI-induced sexual dysfunction. CNS Neurosci Ther. 2008 Fall;14(3):182-91.
http://www.ncbi.nlm.nih.gov/pubmed/18801111
(44) Brooks NA, Wilcox G, Walker KZ et al: Beneficial effects of Lepidium
meyenii (Maca) on psychological symptoms and measures of sexual
dysfunction in postmenopausal women are not related to estrogen or
androgen content. Menopause. 2008 Nov-Dec;15(6):1157-62.
http://www.ncbi.nlm.nih.gov/pubmed/18784609
(45) Wang Y, Wang Y, McNeil B et al: Maca: An Andean Crop with multipharmacological
functions. Food Res Inter. 2007 40:783-92.
http://wenku.baidu.com/view/3c037f18c5da50e2524d7f5e
(46) Lentz A, Gravitt K, Carson CC et al: Acute and chronic dosing of Lepidium
meyenii (Maca) on male rat sexual behavior. J Sex Med. 2007 Mar;4(2):332-9;
discussion 339-40. http://www.ncbi.nlm.nih.gov/pubmed/17367428
(47) Yucra S, Gasco M, Rubio J et al: Effect of different fractions from
hydroalcoholic extract of Black Maca (Lepidium meyenii) on testicular
function in adult male rats. Fertil Steril. 2008 May;89(5 Suppl):1461-7. Epub
2007 Jul 31. http://www.ncbi.nlm.nih.gov/pubmed/17669402
(48) Vecera R, Orolin J, Skottová N et al: The influence of maca (Lepidium
meyenii) on antioxidant status, lipid and glucose metabolism in rat. Plant
Foods Hum Nutr. 2007 Jun;62(2):59-63.
http://www.ncbi.nlm.nih.gov/pubmed/17333395
(49) Gasco M, Aguilar J, Gonzales GF: Effect of chronic treatment with three
varieties of Lepidium meyenii (Maca) on reproductive parameters and DNA
quantification in adult male rats. Andrologia. 2007 Aug;39(4):151-8.
http://www.ncbi.nlm.nih.gov/pubmed/17683465
(50) Gasco M, Villegas L, Yucra S, Rubio J et al: Dose-response effect of Red
Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by
testosterone enanthate. Phytomedicine. 2007 Aug;14(7-8):460-4.
http://www.ncbi.nlm.nih.gov/pubmed/17289361
(51) Rubio J, Dang H, Gong M et al: Aqueous and hydroalcoholic extracts of
Black Maca (Lepidium meyenii) improve scopolamine-induced memory
impairment in mice. Food Chem Toxicol. 2007 Oct;45(10):1882-90. Epub 2007
Apr 20. http://www.ncbi.nlm.nih.gov/pubmed/17543435
(52) Mehta K, Gala J, Bhasale S et al: Comparison of glucosamine sulfate and
a polyherbal supplement for the relief of osteoarthritis of the knee: a
randomized controlled trial [ISRCTN25438351]. BMC Complement Altern
Med. 2007 Oct 31;7:34. http://www.ncbi.nlm.nih.gov/pubmed/17974032
(53) Gonzales GF, Valerio LG Jr: Medicinal plants from Peru: a review of plants
as potential agents against cancer. Anticancer Agents Med Chem. 2006
Sep;6(5):429-44 http://www.ncbi.nlm.nih.gov/pubmed/17017852
(54) Gonzales GF, Nieto J, Rubio J, Gasco M: Effect of Black maca (Lepidium
meyenii) on one spermatogenic cycle in rats. Andrologia. 2006 Oct;38(5):166-
72. http://www.ncbi.nlm.nih.gov/pubmed/16961569
(55) Rubio J, Caldas M, Dávila S et al: Effect of three different cultivars of
Lepidium meyenii (Maca) on learning and depression in ovariectomized mice.
BMC Complement Altern Med. 2006 Jun 23;6:23.
http://www.ncbi.nlm.nih.gov/pubmed/16796734
(56) Miller MJ, Ahmed S, Bobrowski P et al: The chrondoprotective actions of a
natural product are associated with the activation of IGF-1 production by
human chondrocytes despite the presence of IL-1beta. BMC Complement
Altern Med. 2006 Apr 7;6:13. http://www.ncbi.nlm.nih.gov/pubmed/16603065
(57) Valentová K, Buckiová D, Kren V et al: The in vitro biological activity of
Lepidium meyenii extracts.Cell Biol Toxicol. 2006 Mar;22(2):91-9.
http://www.ncbi.nlm.nih.gov/pubmed/16528448
(58) Rubio J, Riqueros MI, Gasco M et al: Lepidium meyenii (Maca) reversed
the lead acetate induced damage on reproductive function in male rats. Food
Chem Toxicol. 2006 Jul;44(7):1114-22.
http://www.ncbi.nlm.nih.gov/pubmed/16510228
(59) Zhang Y, Yu L, Ao M et al: Effect of ethanol extract of Lepidium meyenii
Walp on osteoporosis in ovariectomized rat. J Ethnopharmacol. 2006 Apr
21;105(1-2):274-9. http://www.ncbi.nlm.nih.gov/pubmed/16466876
(60) Bogani P, Simonini F, Iriti M et al: Lepidium meyenii (Maca) does not
exert direct androgenic activities. J Ethnopharmacol. 2006 Apr 6;104(3):415-7.
http://www.ncbi.nlm.nih.gov/pubmed/16239088
(61) Gonzales C, Rubio J, Gasco M et al: Effect of short-term and long-term
treatments with three ecotypes of Lepidium meyenii (MACA) on
spermatogenesis in rats. J Ethnopharmacol. 2006 Feb 20;103(3):448-54.
http://www.ncbi.nlm.nih.gov/pubmed/16174556
(62) Valerio LG Jr, Gonzales GF: Toxicological aspects of the South American
herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii): a critical
synopsis. Toxicol Rev. 2005;24(1):11-35. Review.
http://www.ncbi.nlm.nih.gov/pubmed/16042502
(63) Ruiz-Luna AC, Salazar S, Aspajo NJ et al: Lepidium meyenii (Maca)
increases litter size in normal adult female mice. Reprod Biol Endocrinol.
2005 May 3;3:16. http://www.ncbi.nlm.nih.gov/pubmed/15869705
(64) Chung F, Rubio J, Gonzales C et al: Dose-response effects of Lepidium
meyenii (Maca) aqueous extract on testicular function and weight of different
organs in adult rats. J Ethnopharmacol. 2005 Apr 8;98(1-2):143-7.
http://www.ncbi.nlm.nih.gov/pubmed/15763375
(65) Zhao J, Muhammad I, Dunbar DC et al: New alkamides from maca
(Lepidium meyenii). J Agric Food Chem. 2005 Feb 9;53(3):690-3.
http://www.ncbi.nlm.nih.gov/pubmed/15686421
(66) Bustos-Obregon E, Yucra S et al: Lepidium meyenii (Maca) reduces
spermatogenic damage induced by a single dose of malathion in mice. Asian
J Androl. 2005 Mar;7(1):71-6. http://www.ncbi.nlm.nih.gov/pubmed/15685355
(67) Cui B, Zheng B, He K et al: Imidazole alkaloids from Lepidium meyenii
and methods of usage. USPTO No. 6,878,731. 2005 Apr 12.
http://patft.uspto.gov/netacgi/nph-
Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.
html&r=21&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O
S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii
(68) Gonzales GF, Miranda S, Nieto J et al: Red maca (Lepidium meyenii)
reduced 2005 Jan 20;3:5. http://www.ncbi.nlm.nih.gov/pubmed/15661081
(69) Gonzales GF, Gasco M, Córdova A et al: Effect of Lepidium meyenii
(Maca) on spermatogenesis in male rats acutely exposed to high altitude
(4340 m). J Endocrinol. 2004 Jan;180(1):87-95.
http://www.ncbi.nlm.nih.gov/pubmed/14709147
(70) Bobrowski Paul (PI): Enhanced IGF-1 Production by Human Cartilage.
2004. NIH National Institute on Aging #1R43AG024733-01.
http://projectreporter.nih.gov/project_info_description.cfm?aid=6834041&icd
e=0
(71) Zheng B, He K, Shao Y et al: Compositions and methods for their
preparation from lepidium. USPTO No. 6,552,206. 2003 Apr 22.
http://patft.uspto.gov/netacgi/nph-
Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.
html&r=22&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O
S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii
(72) Valentová K, Ulrichová J: Smallanthus sonchifolius and Lepidium meyenii
- prospective Andean crops for the prevention of chronic diseases. Biomed
Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Dec;147(2):119-30.
http://www.ncbi.nlm.nih.gov/pubmed/15037892
(73) Gonzales GF, Rubio J, Chung A et al: Effect of alcoholic extract of
Lepidium meyenii (Maca) on testicular function in male rats. Asian J Androl.
2003 Dec;5(4):349-52. http://www.ncbi.nlm.nih.gov/pubmed/14695987
(74) Comhaire FH, Mahmoud A: The role of food supplements in the
treatment of the infertile man. Reprod Biomed Online. 2003 Oct-
Nov;7(4):385-91. http://www.ncbi.nlm.nih.gov/pubmed/14656398
(75) Oshima M, Gu Y, Tsukada S: Effects of Lepidium meyenii Walp and
Jatropha macrantha on blood levels of estradiol-17 beta, progesterone,
testosterone and the rate of embryo implantation in mice. J Vet Med Sci.
2003 Oct;65(10):1145-6. http://www.ncbi.nlm.nih.gov/pubmed/14600359
(76) Cui B, Zheng BL, He K et al: Imidazole alkaloids from Lepidium meyenii. J
Nat Prod. 2003 Aug;66(8):1101-3.
http://www.ncbi.nlm.nih.gov/pubmed/12932133
(77) Gonzales GF, Córdova A, Vega K et al: Effect of Lepidium meyenii (Maca),
a root with aphrodisiac and fertility-enhancing properties, on serum
reproductive hormone levels in adult healthy men. J Endocrinol. 2003
Jan;176(1):163-8. http://www.ncbi.nlm.nih.gov/pubmed/12525260
(78) Cicero AF, Piacente S, Plaza A et al: Hexanic Maca extract improves rat
sexual performance more effectively than methanolic and chloroformic Maca
extracts. Andrologia. 2002 Jun;34(3):177-9.
http://www.ncbi.nlm.nih.gov/pubmed/12059814
(79) Sandoval M, Okuhama NN, Angeles FMet al: Antioxidant activity of the
cruciferous vegetable Maca (Lepidium meyenii) Food Chemistry 2002. 79:
207-213.
http://www.sciencedirect.com/science/article/pii/S0308814602001334
(80) Zheng B, Kim C, Wolthoff S et al: Treatment of sexual dysfunction with an
extract of Lepidium meyenii roots. USPTO No. 6,428,824. 2002 Aug 6.
http://patft.uspto.gov/netacgi/nph-
Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.
html&r=24&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O
S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii
(81) Piacente S, Carbone V, Plaza A et al: Investigation of the tuber
constituents of maca (Lepidium meyenii Walp.). J Agric Food Chem. 2002 Sep
25;50(20):5621-5. http://www.ncbi.nlm.nih.gov/pubmed/12236688
(82) Gonzales GF, Córdova A, Vega K et al: Effect of Lepidium meyenii (MACA)
on sexual desire and its absent relationship with serum testosterone levels in
adult healthy men. Andrologia. 2002 Dec;34(6):367-72.
http://www.ncbi.nlm.nih.gov/pubmed/12472620
(83) Muhammad I, Zhao J, Dunbar DC et al: Constituents of Lepidium meyenii
'maca'. Phytochemistry. 2002 Jan;59(1):105-10.
http://www.ncbi.nlm.nih.gov/pubmed/11754952
(84) Zheng B, Kim C, Wolthoff S et al: Extract of Lepidium meyenii roots for
pharmaceutical applications. USPTO No. 6,267,995. 2001 Jul 31.
http://patft.uspto.gov/netacgi/nph-
Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.
html&r=25&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O
S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii
(85) Gonzales GF, Cordova A, Gonzales C et al: Lepidium meyenii (Maca)
improved semen parameters in adult men. Asian J Androl. 2001 Dec;3(4):301-
3. http://www.ncbi.nlm.nih.gov/pubmed/11753476
(86) Gonzales GF, Ruiz A, Gonzales C et al: Effect of Lepidium meyenii (maca)
roots on spermatogenesis of male rats. Asian J Androl. 2001 Sep;3(3):231-3.
http://www.ncbi.nlm.nih.gov/pubmed/11561196
(87) Cicero AF, Bandieri E, Arletti R: Lepidium meyenii Walp. improves sexual
behavior in male rats independently from its action on spontaneous
locomotor activity. J Ethnopharmacol. 2001 May;75(2-3):225-9.
http://www.ncbi.nlm.nih.gov/pubmed/11297856
(88) Canales M, Aguilar J, Prada A et al: Nutritional evaluation of Lepidium
meyenii (MACA) in albino mice and their descendants. Arch Latinoam Nutr.
2000 Jun;50(2):126-33 (Spanish).
http://www.ncbi.nlm.nih.gov/pubmed/11048583
(89) Zheng BL, He K, Kim CH et al: Effect of a lipidic extract from Lepidium
meyenii on sexual behavior in mice and rats. Urology. 2000 Apr;55(4):598-
602. http://www.ncbi.nlm.nih.gov/pubmed/10736519
Additional Studies:
-
Barzilai N, Huffman D, Muzumdar R et al: The Critical Role of Metabolic Pathways in Aging. Diabetes. 2012. 61(6):1315-1322
-
Bobrowski P (PI): Enhanced IGF-1 Production in Human Cartilage. Grant No. 1R43AG024733-01, US National Institutes of Health (NIH): National Institute on Aging & National Institute of Arthritis and Musculoskeletal Disease. 2004-2005.
-
Bobrowski, PJ: Methods and compositions to enhance endogenous IGF production and their use. USPTO No. 8182847: 2012 May 22.
-
Brugts M, Ranke M, Hofland L et al: Normal Values of Circulating Insulin-Like Growth Factor-I Bioactivity in the Healthy Population: Comparison with Five Widely Used IGF-I Immunoassays. J Clin Endocrinol Metab. 2008. 93(7):2539–2545.
-
Gong Z, Kennedy O, Sun H et al: Reductions in serum IGF-1 during aging impair health span. Aging Cell. 2014. 13(3):408-18.
-
Juul A, Bang P, Hertel N at al: Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. J Clin Endocrinol Metab. 1994. 78(3):744-52.
-
Mehta K, Gala J, Bhasale S et al: Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. BMC Comp Alt Med. 2007. 7:34.
-
Miller M, Ahmed S, Bobrowski P et al: The chondroprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006. 6:13.
-
Noordam R, Gunn D, Tomlin C et al: Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study. Br J Dermatol. 2013. 168(3):533-8.
-
O'Neill C, Kiely A, Coakley M et al: Insulin and IGF-1 signaling: longevity, protein homoeostasis and Alzheimer's disease. Biochem Soc Trans. 2012. 40(4):721-7.
-
Sandovala M, Okuhama N, Angeles F et al: Antioxidant activity of the cruciferous vegetable Maca (Lepidium meyenii). Food Chemistry, 2002, 79: 207-213. (Download PDF #10)
-
Sjögren K, Jansson J, Isaksson O et al: A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I. Endocrine. 2002. 19(3):249-56.
-
Xu S, Gu X, Pan H et al: Reference ranges for serum IGF-1 and IGFBP-3 levels in Chinese children during childhood and adolescence. Endocr J. 2010. 57(3):221-8.
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