Miracle Anti-Aging Breakthrough! 

RNI249®  Benefits:

RNI249® - Is a Patented, Highly Concentrated Substance: 

(Support studies under "Scientific Studies")

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• RNI249® Is the only known natural substance or pharmaceutical shown to increase endogenous IGF-1 in human cells

• Research supported by two National Institutes of Health: National Institute of Aging and the National Institute of Arthritis and Musculoskeletal Disease

 Helps Support:

1. Endogenous IGF-1 Secretion

2. Healthy Aging

RNI 249® is a patented extract from the hypocotyls of the crucifer Lepidium meyenii (aka “Maca”), a radish-like tuber cultivated only on the inner slopes of the Andean Mountains.  In a study with Case Western Reserve University, it has been shown to increase human cellular production of IGF-1 and in a clinical trial, together with Vincaria®, was an effective treatment for osteoporosis. 

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The pituitary gland in the brain secretes human growth hormone (HGH) which in turn signals (primarily) the liver to produce and secrete insulin like growth factor 1 (IGF-1).   Both HGH and IGF-1 promote whole body growth and their levels peak during puberty.  IGF-1 increases protein synthesis (muscle growth), bone mineralization, low blood sugar, kidney function and insulin sensitivity.  It promotes healing and repair of bone, muscle, nervous system and immune system cells.

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Following puberty when its levels are at their peak, as we age, IGF-1 levels precipitously decline such that by the time we are 60 years old, the levels have decreased by approximately eighty percent (80%).

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This natural decline in IGF-1 levels in adulthood, known as somatopause, is responsible for most of the signs we associate with aging.  These include but are not limited to altered musculoskeletal function (e.g. muscle atrophy; associated decrease in strength; bone calcium loss/osteoporosis); altered endocrine function (i.e. a higher incidence of diabetes); altered carbohydrate and lipid metabolism; altered Integumentary function (e.g. skin thinning, wrinkles); and, altered neurological function (e.g. dementia, Alzheimer disease).

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To date, RNI 249 is the only substance, natural or pharmaceutical, which has been shown to increase the body’s natural production of IGF.

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As proof of principle, researchers subsequently conducted a human clinical trial, sponsored in part by the NIH/NIA, in subjects with confirmed osteoarthritis. Within the 30-day period of the trial and then for most within seven days, 94% of the participants had a statistically significant improvement in mobility and flexibility and in comparison to the positive control glucosamine, a marked reduction in pain.

Ingredient: RNI249® - Works Cited:

(1) Andrews K, Grunebaum AN: Composition and method for fertility therapy

using nutritional supplements. USPTO No. 8,663,709. 2014 Mar 4.

http://patft.uspto.gov/netacgi/nph-

Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%

2Fsrchnum.htm&r=1&f=G&l=50&s1=8,663,709.PN.&OS=PN/8,663,709&RS=P

N/8,663,709

(2) Zhang Y, Yu L, Jin W, Ao M: Effect of ethanolic extract of Lepidium meyenii

Walp on serum hormone levels in ovariectomized rats. Indian J Pharmacol.

2014 Jul;46(4):416-9. http://www.ncbi.nlm.nih.gov/pubmed/25097281

(3) Zha S, Zhao Q, Chen J et al: Extraction, purification and antioxidant

activities of the polysaccharides from maca (Lepidium meyenii). Carbohydr

Polym. 2014 Oct 13;111:584-7.

http://www.ncbi.nlm.nih.gov/pubmed/25037390

(4) Hajdu Z, Nicolussi S, Rau M et al: Identification of Endocannabinoid

System-Modulating N-Alkylamides from Heliopsis helianthoides var. scabra

and Lepidium meyenii. J Nat Prod. 2014 Jul 25;77(7):1663-9.

http://www.ncbi.nlm.nih.gov/pubmed/24972328

(5) Stojanovska L, Law C, Lai B et al Maca reduces blood pressure and

depression, in a pilot study in postmenopausal women. Climacteric. 2014

Aug 7:1-10. http://www.ncbi.nlm.nih.gov/pubmed/24931003

(6) Ai Z, Cheng AF, Yu YT et al: Antidepressant-like behavioral, anatomical, and

biochemical effects of petroleum ether extract from maca (Lepidium

meyenii) in mice exposed to chronic unpredictable mild stress. J Med Food.

2014 May;17(5):535-42. http://www.ncbi.nlm.nih.gov/pubmed/24730393

(7) Benites Goñi HE, Cok García J, Bussalleu Cavero A et al: Assesing the effect

of Lepidium meyenii "Maca" on the gastric mucosa in patients with functional

dyspepsia. Rev Gastroenterol Peru. 2014 Jan-Mar;34(1):39-43 (Spanish).

http://www.ncbi.nlm.nih.gov/pubmed/24721957

(8) Gonzales GF, Villaorduña L, Gasco M, Rubio J et al: Maca (Lepidium

meyenii Walp), a review of its biological properties. Rev Peru Med Exp Salud

Publica. 2014;31(1):100-10 (Spanish).

http://www.ncbi.nlm.nih.gov/pubmed/24718534

(9) Lembè DM, Gasco M, Gonzales GF:Synergistic effect of the hydroalcoholic

extract from Lepidium meyenii (Brassicaceae) and Fagara tessmannii

(Rutaceae) on male sexual organs and hormone level in rats. Pharmacognosy

Res. 2014 Jan;6(1):80-6. http://www.ncbi.nlm.nih.gov/pubmed/24497748

(10) Uchiyama F, Jikyo T, Takeda R et al: Lepidium meyenii (Maca) enhances

the serum levels of luteinising hormone in female rats. J Ethnopharmacol.

2014 Feb 3;151(2):897-902. http://www.ncbi.nlm.nih.gov/pubmed/24333960

(11) Gonzales GF, Gasco M, Lozada-Requena I: Role of maca (Lepidium

meyenii) consumption on serum interleukin-6 levels and health status in

populations living in the Peruvian Central Andes over 4000 m of altitude.

Plant Foods Hum Nutr. 2013 Dec;68(4):347-51.

http://www.ncbi.nlm.nih.gov/pubmed/23934543

(12) Wu H, Kelley CJ, Pino-Figueroa A et al: Macamides and their synthetic

analogs: evaluation of in vitro FAAH inhibition. Bioorg Med Chem. 2013 Sep

1;21(17):5188-97. http://www.ncbi.nlm.nih.gov/pubmed/23891163

(13) Almukadi H, Wu H, Böhlke M et al: The macamide N-3-methoxybenzyllinoleamide

is a time-dependent fatty acid amide hydrolase (FAAH) inhibitor.

Mol Neurobiol. 2013 Oct;48(2):333-9.

http://www.ncbi.nlm.nih.gov/pubmed/23853040

(14) Gonzales GF, Vasquez VB, Gasco M: The transillumination technique as a

method for the assessment of spermatogenesis using medicinal plants: the

effect of extracts of black maca (Lepidium meyenii) and camu camu

(Myrciaria dubia) on stages of the spermatogenic cycle in male rats. Toxicol

Mech Methods. 2013 Oct;23(8):559-65.

http://www.ncbi.nlm.nih.gov/pubmed/23650963

(15) Gonzales GF, Gonzales-Castañeda C, Gasco M: A mixture of extracts from

Peruvian plants (black maca and yacon) improves sperm count and reduced

glycemia in mice with streptozotocin-induced diabetes. Toxicol Mech

Methods. 2013 Sep;23(7):509-18.

http://www.ncbi.nlm.nih.gov/pubmed/23489070

(16) Shrivastava A, Gupta VB: Various treatment options for benign prostatic

hyperplasia: A current update. J Midlife Health. 2012 Jan;3(1):10-9.

http://www.ncbi.nlm.nih.gov/pubmed/22923974

(17) Clément C, Witschi U, Kreuzer M: The potential influence of plant-based

feed supplements on sperm quantity and quality in livestock: a review. Anim

Reprod Sci. 2012 May;132(1-2):1-10.

http://www.ncbi.nlm.nih.gov/pubmed/22575847

(18) Bobrowski, PJ: Methods and compositions to enhance endogenous IGF

production and their use. USPTO No. 8182847: 2012 May 22.

http://patft.uspto.gov/netacgi/nph-

Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.

html&r=11&f=G&l=50&co1=AND&d=PTXT&s1=Paul&s2=Bobrowski&OS=

Paul+AND+Bobrowski&RS=Paul+AND+Bobrowski

(19) Gonzales GF: Ethnobiology and Ethnopharmacology of Lepidium meyenii

(Maca), a Plant from the Peruvian Highlands. Evid Based Complement

Alternat Med. 2012; 2012:193496.

http://www.ncbi.nlm.nih.gov/pubmed/21977053

(20) Zhao J, Avula B, Chan M et al: Metabolomic differentiation of maca

(Lepidium meyenii) accessions cultivated under different conditions using

NMR and chemometric analysis. Planta Med. 2012 Jan;78(1):90-101.

http://www.ncbi.nlm.nih.gov/pubmed/21858755

(21) Bobrowski P: Methods and compositions to enhance endogenous IGF

production and their uses. USPTO 8,182,847: May 22, 2012.

(22) Akhtar N, Miller MJ, Haqqi TM: Effect of a Herbal-Leucine mix on the IL-

1β-induced cartilage degradation and inflammatory gene expression in

human chondrocytes. BMC Complement Altern Med. 2011 Aug 19;11:66.

http://www.ncbi.nlm.nih.gov/pubmed/21854562

(23) Lee MS, Shin BC, Yang EJ et al: Maca (Lepidium meyenii) for treatment of

menopausal symptoms: A systematic review. Maturitas. 2011 Nov;70(3):227-

33. http://www.ncbi.nlm.nih.gov/pubmed/21840656

(24) Gonzales-Castañeda C, Rivera V, Chirinos AL et al: Photoprotection

against the UVB-induced oxidative stress and epidermal damage in mice

using leaves of three different varieties of Lepidium meyenii (maca).

(25) Int J Dermatol. 2011 Aug;50(8):928-38.

http://www.ncbi.nlm.nih.gov/pubmed/21781063

(26) Rubio J, Yucra S, Gasco M et al: Dose-response effect of black maca

(Lepidium meyenii) in mice with memory impairment induced by ethanol.

Toxicol Mech Methods. 2011 Oct;21(8):628-34.

http://www.ncbi.nlm.nih.gov/pubmed/21780878

(27) Rubio J, Qiong W, Liu X et al: Aqueous Extract of Black Maca (Lepidium

meyenii) on Memory Impairment Induced by Ovariectomy in Mice. Evid

Based Complement Alternat Med. 2011;2011:253958.

http://www.ncbi.nlm.nih.gov/pubmed/18955369

(28) Gonzales C, Leiva-Revilla J, Rubio J et al: Effect of red maca (Lepidium

meyenii) on prostate zinc levels in rats with testosterone-induced prostatic

hyperplasia. Andrologia. 2012 May;44 Suppl 1:362-9.

http://www.ncbi.nlm.nih.gov/pubmed/21762188

(29) Clément C, Diaz Grados DA, Avula B et al: Influence of colour type and

previous cultivation on secondary metabolites in hypocotyls and leaves of

maca (Lepidium meyenii Walpers). J Sci Food Agric. 2010 Apr 15;90(5):861-9.

http://www.ncbi.nlm.nih.gov/pubmed/20355123

(30) Mazaro-Costa R, Andersen ML, Hachul H, Tufik S.: Medicinal plants as

alternative treatments for female sexual dysfunction: utopian vision or

possible treatment in climacteric women? J Sex Med. 2010 Nov; 7(11):3695-

714. http://www.ncbi.nlm.nih.gov/pubmed/20722793

(31) Zheng BL, He K, Shao Y et al: Compositions and methods for their

preparation from lepidium. USPTO No. RE43,005. 2001 Dec 6.

http://patft.uspto.gov/netacgi/nphParser?

Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.

html&r=11&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O

S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii

(32) Pino-Figueroa A, Nguyen D, Maher TJ: Neuroprotective effects of

Lepidium meyenii (Maca). Ann N Y Acad Sci. 2010 Jun;1199:77-85.

http://www.ncbi.nlm.nih.gov/pubmed/20633111

(33) Ranilla LG, Kwon YI, Apostolidis E et al: Phenolic compounds, antioxidant

activity and in vitro inhibitory potential against key enzymes relevant for

hyperglycemia and hypertension of commonly used medicinal plants, herbs

and spices in Latin America. Bioresour Technol. 2010 Jun;101(12):4676-89.

http://www.ncbi.nlm.nih.gov/pubmed/20185303

(34) Clément C, Kneubühler J, Urwyler A et al: Effect of maca supplementation

on bovine sperm quantity and quality followed over two spermatogenic

cycles. Theriogenology. 2010 Jul 15;74(2):173-83.

http://www.ncbi.nlm.nih.gov/pubmed/20452008

(35) Shin BC, Lee MS, Yang EJ et al: Maca (L. meyenii) for improving sexual

function: a systematic review.BMC Complement Altern Med. 2010 Aug

6;10:44. http://www.ncbi.nlm.nih.gov/pubmed/20691074

(36) Gonzales C, Cárdenas-Valencia I, Leiva-Revilla J et al: Effects of different

varieties of Maca (Lepidium meyenii) on bone structure in ovariectomized

rats. Forsch Komplementmed. 2010;17(3):137-43.

http://www.ncbi.nlm.nih.gov/pubmed/20616517

(37) Gonzales GF, Gonzales C, Gonzales-Castañeda C: Lepidium meyenii

(Maca): a plant from the highlands of Peru--from tradition to science. Forsch

Komplementmed. 2009 Dec;16(6):373-80.

http://www.ncbi.nlm.nih.gov/pubmed/20090350

(38) Stone M, Ibarra A, Roller M et al: A pilot investigation into the effect of

maca supplementation on physical activity and sexual desire in sportsmen. J

Ethnopharmacol. 2009 Dec 10;126(3):574-6.

http://www.ncbi.nlm.nih.gov/pubmed/19781622

(39) Zenico T, Cicero AF, Valmorri L et al: Subjective effects of Lepidium

meyenii (Maca) extract on well-being and sexual performances in patients

with mild erectile dysfunction: a randomized, double-blind clinical trial.

Andrologia. 2009 Apr;41(2):95-9.

http://www.ncbi.nlm.nih.gov/pubmed/19260845

(40) Gonzales-Castañeda C, Gonzales GF: Hypocotyls of Lepidium meyenii

(maca), a plant of the Peruvian highlands, prevent ultraviolet A-, B-, and Cinduced

skin damage in rats. Photodermatol Photoimmunol Photomed. 2008

Feb;24(1):24-31. http://www.ncbi.nlm.nih.gov/pubmed/18201354

(41) Valentová K, Stejskal D, Bartek J et al: Maca (Lepidium meyenii) and

yacon (Smallanthus sonchifolius) in combination with silymarin as food

supplements: in vivo safety assessment. Food Chem Toxicol. 2008

Mar;46(3):1006-13. http://www.ncbi.nlm.nih.gov/pubmed/18054420

(42) Gonzales GF, Gasco M, Malheiros-Pereira A et al: Antagonistic effect of

Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice.

Andrologia. 2008 Jun;40(3):179-85.

http://www.ncbi.nlm.nih.gov/pubmed/18477205

(43) Dording CM, Fisher L, Papakostas G et al: A double-blind, randomized,

pilot dose-finding study of maca root (L. meyenii) for the management of

SSRI-induced sexual dysfunction. CNS Neurosci Ther. 2008 Fall;14(3):182-91.

http://www.ncbi.nlm.nih.gov/pubmed/18801111

(44) Brooks NA, Wilcox G, Walker KZ et al: Beneficial effects of Lepidium

meyenii (Maca) on psychological symptoms and measures of sexual

dysfunction in postmenopausal women are not related to estrogen or

androgen content. Menopause. 2008 Nov-Dec;15(6):1157-62.

http://www.ncbi.nlm.nih.gov/pubmed/18784609

(45) Wang Y, Wang Y, McNeil B et al: Maca: An Andean Crop with multipharmacological

functions. Food Res Inter. 2007 40:783-92.

http://wenku.baidu.com/view/3c037f18c5da50e2524d7f5e

(46) Lentz A, Gravitt K, Carson CC et al: Acute and chronic dosing of Lepidium

meyenii (Maca) on male rat sexual behavior. J Sex Med. 2007 Mar;4(2):332-9;

discussion 339-40. http://www.ncbi.nlm.nih.gov/pubmed/17367428

(47) Yucra S, Gasco M, Rubio J et al: Effect of different fractions from

hydroalcoholic extract of Black Maca (Lepidium meyenii) on testicular

function in adult male rats. Fertil Steril. 2008 May;89(5 Suppl):1461-7. Epub

2007 Jul 31. http://www.ncbi.nlm.nih.gov/pubmed/17669402

(48) Vecera R, Orolin J, Skottová N et al: The influence of maca (Lepidium

meyenii) on antioxidant status, lipid and glucose metabolism in rat. Plant

Foods Hum Nutr. 2007 Jun;62(2):59-63.

http://www.ncbi.nlm.nih.gov/pubmed/17333395

(49) Gasco M, Aguilar J, Gonzales GF: Effect of chronic treatment with three

varieties of Lepidium meyenii (Maca) on reproductive parameters and DNA

quantification in adult male rats. Andrologia. 2007 Aug;39(4):151-8.

http://www.ncbi.nlm.nih.gov/pubmed/17683465

(50) Gasco M, Villegas L, Yucra S, Rubio J et al: Dose-response effect of Red

Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by

testosterone enanthate. Phytomedicine. 2007 Aug;14(7-8):460-4.

http://www.ncbi.nlm.nih.gov/pubmed/17289361

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(51) Rubio J, Dang H, Gong M et al: Aqueous and hydroalcoholic extracts of

Black Maca (Lepidium meyenii) improve scopolamine-induced memory

impairment in mice. Food Chem Toxicol. 2007 Oct;45(10):1882-90. Epub 2007

Apr 20. http://www.ncbi.nlm.nih.gov/pubmed/17543435

(52) Mehta K, Gala J, Bhasale S et al: Comparison of glucosamine sulfate and

a polyherbal supplement for the relief of osteoarthritis of the knee: a

randomized controlled trial [ISRCTN25438351]. BMC Complement Altern

Med. 2007 Oct 31;7:34. http://www.ncbi.nlm.nih.gov/pubmed/17974032

(53) Gonzales GF, Valerio LG Jr: Medicinal plants from Peru: a review of plants

as potential agents against cancer. Anticancer Agents Med Chem. 2006

Sep;6(5):429-44 http://www.ncbi.nlm.nih.gov/pubmed/17017852

(54) Gonzales GF, Nieto J, Rubio J, Gasco M: Effect of Black maca (Lepidium

meyenii) on one spermatogenic cycle in rats. Andrologia. 2006 Oct;38(5):166-

72. http://www.ncbi.nlm.nih.gov/pubmed/16961569

(55) Rubio J, Caldas M, Dávila S et al: Effect of three different cultivars of

Lepidium meyenii (Maca) on learning and depression in ovariectomized mice.

BMC Complement Altern Med. 2006 Jun 23;6:23.

http://www.ncbi.nlm.nih.gov/pubmed/16796734

(56) Miller MJ, Ahmed S, Bobrowski P et al: The chrondoprotective actions of a

natural product are associated with the activation of IGF-1 production by

human chondrocytes despite the presence of IL-1beta. BMC Complement

Altern Med. 2006 Apr 7;6:13. http://www.ncbi.nlm.nih.gov/pubmed/16603065

(57) Valentová K, Buckiová D, Kren V et al: The in vitro biological activity of

Lepidium meyenii extracts.Cell Biol Toxicol. 2006 Mar;22(2):91-9.

http://www.ncbi.nlm.nih.gov/pubmed/16528448

(58) Rubio J, Riqueros MI, Gasco M et al: Lepidium meyenii (Maca) reversed

the lead acetate induced damage on reproductive function in male rats. Food

Chem Toxicol. 2006 Jul;44(7):1114-22.

http://www.ncbi.nlm.nih.gov/pubmed/16510228

(59) Zhang Y, Yu L, Ao M et al: Effect of ethanol extract of Lepidium meyenii

Walp on osteoporosis in ovariectomized rat. J Ethnopharmacol. 2006 Apr

21;105(1-2):274-9. http://www.ncbi.nlm.nih.gov/pubmed/16466876

(60) Bogani P, Simonini F, Iriti M et al: Lepidium meyenii (Maca) does not

exert direct androgenic activities. J Ethnopharmacol. 2006 Apr 6;104(3):415-7.

http://www.ncbi.nlm.nih.gov/pubmed/16239088

(61) Gonzales C, Rubio J, Gasco M et al: Effect of short-term and long-term

treatments with three ecotypes of Lepidium meyenii (MACA) on

spermatogenesis in rats. J Ethnopharmacol. 2006 Feb 20;103(3):448-54.

http://www.ncbi.nlm.nih.gov/pubmed/16174556

​

(62) Valerio LG Jr, Gonzales GF: Toxicological aspects of the South American

herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii): a critical

synopsis. Toxicol Rev. 2005;24(1):11-35. Review.

http://www.ncbi.nlm.nih.gov/pubmed/16042502

(63) Ruiz-Luna AC, Salazar S, Aspajo NJ et al: Lepidium meyenii (Maca)

increases litter size in normal adult female mice. Reprod Biol Endocrinol.

2005 May 3;3:16. http://www.ncbi.nlm.nih.gov/pubmed/15869705

(64) Chung F, Rubio J, Gonzales C et al: Dose-response effects of Lepidium

meyenii (Maca) aqueous extract on testicular function and weight of different

organs in adult rats. J Ethnopharmacol. 2005 Apr 8;98(1-2):143-7.

http://www.ncbi.nlm.nih.gov/pubmed/15763375

(65) Zhao J, Muhammad I, Dunbar DC et al: New alkamides from maca

(Lepidium meyenii). J Agric Food Chem. 2005 Feb 9;53(3):690-3.

http://www.ncbi.nlm.nih.gov/pubmed/15686421

(66) Bustos-Obregon E, Yucra S et al: Lepidium meyenii (Maca) reduces

spermatogenic damage induced by a single dose of malathion in mice. Asian

J Androl. 2005 Mar;7(1):71-6. http://www.ncbi.nlm.nih.gov/pubmed/15685355

(67) Cui B, Zheng B, He K et al: Imidazole alkaloids from Lepidium meyenii

and methods of usage. USPTO No. 6,878,731. 2005 Apr 12.

http://patft.uspto.gov/netacgi/nph-

Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.

html&r=21&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O

S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii

(68) Gonzales GF, Miranda S, Nieto J et al: Red maca (Lepidium meyenii)

reduced 2005 Jan 20;3:5. http://www.ncbi.nlm.nih.gov/pubmed/15661081

(69) Gonzales GF, Gasco M, Córdova A et al: Effect of Lepidium meyenii

(Maca) on spermatogenesis in male rats acutely exposed to high altitude

(4340 m). J Endocrinol. 2004 Jan;180(1):87-95.

http://www.ncbi.nlm.nih.gov/pubmed/14709147

(70) Bobrowski Paul (PI): Enhanced IGF-1 Production by Human Cartilage.

2004. NIH National Institute on Aging #1R43AG024733-01.

http://projectreporter.nih.gov/project_info_description.cfm?aid=6834041&icd

e=0

(71) Zheng B, He K, Shao Y et al: Compositions and methods for their

preparation from lepidium. USPTO No. 6,552,206. 2003 Apr 22.

http://patft.uspto.gov/netacgi/nph-

Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.

html&r=22&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O

S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii

(72) Valentová K, Ulrichová J: Smallanthus sonchifolius and Lepidium meyenii

- prospective Andean crops for the prevention of chronic diseases. Biomed

Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Dec;147(2):119-30.

http://www.ncbi.nlm.nih.gov/pubmed/15037892

(73) Gonzales GF, Rubio J, Chung A et al: Effect of alcoholic extract of

Lepidium meyenii (Maca) on testicular function in male rats. Asian J Androl.

2003 Dec;5(4):349-52. http://www.ncbi.nlm.nih.gov/pubmed/14695987

(74) Comhaire FH, Mahmoud A: The role of food supplements in the

treatment of the infertile man. Reprod Biomed Online. 2003 Oct-

Nov;7(4):385-91. http://www.ncbi.nlm.nih.gov/pubmed/14656398

(75) Oshima M, Gu Y, Tsukada S: Effects of Lepidium meyenii Walp and

Jatropha macrantha on blood levels of estradiol-17 beta, progesterone,

testosterone and the rate of embryo implantation in mice. J Vet Med Sci.

2003 Oct;65(10):1145-6. http://www.ncbi.nlm.nih.gov/pubmed/14600359

(76) Cui B, Zheng BL, He K et al: Imidazole alkaloids from Lepidium meyenii. J

Nat Prod. 2003 Aug;66(8):1101-3.

http://www.ncbi.nlm.nih.gov/pubmed/12932133

(77) Gonzales GF, Córdova A, Vega K et al: Effect of Lepidium meyenii (Maca),

a root with aphrodisiac and fertility-enhancing properties, on serum

reproductive hormone levels in adult healthy men. J Endocrinol. 2003

Jan;176(1):163-8. http://www.ncbi.nlm.nih.gov/pubmed/12525260

(78) Cicero AF, Piacente S, Plaza A et al: Hexanic Maca extract improves rat

sexual performance more effectively than methanolic and chloroformic Maca

extracts. Andrologia. 2002 Jun;34(3):177-9.

http://www.ncbi.nlm.nih.gov/pubmed/12059814

(79) Sandoval M, Okuhama NN, Angeles FMet al: Antioxidant activity of the

cruciferous vegetable Maca (Lepidium meyenii) Food Chemistry 2002. 79:

207-213.

http://www.sciencedirect.com/science/article/pii/S0308814602001334

(80) Zheng B, Kim C, Wolthoff S et al: Treatment of sexual dysfunction with an

extract of Lepidium meyenii roots. USPTO No. 6,428,824. 2002 Aug 6.

http://patft.uspto.gov/netacgi/nph-

Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.

html&r=24&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O

S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii

(81) Piacente S, Carbone V, Plaza A et al: Investigation of the tuber

constituents of maca (Lepidium meyenii Walp.). J Agric Food Chem. 2002 Sep

25;50(20):5621-5. http://www.ncbi.nlm.nih.gov/pubmed/12236688

(82) Gonzales GF, Córdova A, Vega K et al: Effect of Lepidium meyenii (MACA)

on sexual desire and its absent relationship with serum testosterone levels in

adult healthy men. Andrologia. 2002 Dec;34(6):367-72.

http://www.ncbi.nlm.nih.gov/pubmed/12472620

(83) Muhammad I, Zhao J, Dunbar DC et al: Constituents of Lepidium meyenii

'maca'. Phytochemistry. 2002 Jan;59(1):105-10.

http://www.ncbi.nlm.nih.gov/pubmed/11754952

(84) Zheng B, Kim C, Wolthoff S et al: Extract of Lepidium meyenii roots for

pharmaceutical applications. USPTO No. 6,267,995. 2001 Jul 31.

http://patft.uspto.gov/netacgi/nph-

Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearchbool.

html&r=25&f=G&l=50&co1=AND&d=PTXT&s1=Lepidium&s2=meyenii&O

S=Lepidium+AND+meyenii&RS=Lepidium+AND+meyenii

(85) Gonzales GF, Cordova A, Gonzales C et al: Lepidium meyenii (Maca)

improved semen parameters in adult men. Asian J Androl. 2001 Dec;3(4):301-

3. http://www.ncbi.nlm.nih.gov/pubmed/11753476

(86) Gonzales GF, Ruiz A, Gonzales C et al: Effect of Lepidium meyenii (maca)

roots on spermatogenesis of male rats. Asian J Androl. 2001 Sep;3(3):231-3.

http://www.ncbi.nlm.nih.gov/pubmed/11561196

(87) Cicero AF, Bandieri E, Arletti R: Lepidium meyenii Walp. improves sexual

behavior in male rats independently from its action on spontaneous

locomotor activity. J Ethnopharmacol. 2001 May;75(2-3):225-9.

http://www.ncbi.nlm.nih.gov/pubmed/11297856

(88) Canales M, Aguilar J, Prada A et al: Nutritional evaluation of Lepidium

meyenii (MACA) in albino mice and their descendants. Arch Latinoam Nutr.

2000 Jun;50(2):126-33 (Spanish).

http://www.ncbi.nlm.nih.gov/pubmed/11048583

(89) Zheng BL, He K, Kim CH et al: Effect of a lipidic extract from Lepidium

meyenii on sexual behavior in mice and rats. Urology. 2000 Apr;55(4):598-

602. http://www.ncbi.nlm.nih.gov/pubmed/10736519

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Additional Studies: 

1. Barzilai N, Huffman D, Muzumdar R et al: The Critical Role of Metabolic Pathways in Aging. Diabetes. 2012. 61(6):1315-1322

2. Bobrowski P (PI): Enhanced IGF-1 Production in Human Cartilage. Grant No. 1R43AG024733-01, US National Institutes of Health (NIH): National Institute on Aging & National Institute of Arthritis and Musculoskeletal Disease. 2004-2005.

3. Bobrowski, PJ: Methods and compositions to enhance endogenous IGF production and their use. USPTO No. 8182847: 2012 May 22. 

4. Brugts M, Ranke M, Hofland L et al: Normal Values of Circulating Insulin-Like Growth Factor-I Bioactivity in the Healthy Population: Comparison with Five Widely Used IGF-I Immunoassays. J Clin Endocrinol Metab. 2008. 93(7):2539–2545.

5. Gong Z, Kennedy O, Sun H et al: Reductions in serum IGF-1 during aging impair health span. Aging Cell. 2014. 13(3):408-18.

6. Juul A, Bang P, Hertel N at al: Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. J Clin Endocrinol Metab. 1994. 78(3):744-52.

7. Mehta K, Gala J, Bhasale S et al: Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. BMC Comp Alt Med. 2007. 7:34. 

8. Miller M, Ahmed S, Bobrowski P et al: The chondroprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006. 6:13.

9. Noordam R, Gunn D, Tomlin C et al: Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study. Br J Dermatol. 2013. 168(3):533-8.

10. O'Neill C, Kiely A, Coakley M et al: Insulin and IGF-1 signaling: longevity, protein homoeostasis and Alzheimer's disease. Biochem Soc Trans. 2012. 40(4):721-7. 

11. Sandovala M, Okuhama N, Angeles F et al: Antioxidant activity of the cruciferous vegetable Maca (Lepidium meyenii). Food Chemistry, 2002, 79: 207-213. (Download PDF #10)

12. Sjögren K, Jansson J, Isaksson O et al: A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived IGF-I. Endocrine. 2002. 19(3):249-56.

13. Xu S, Gu X, Pan H et al: Reference ranges for serum IGF-1 and IGFBP-3 levels in Chinese children during childhood and adolescence. Endocr J. 2010. 57(3):221-8.